Как правильно написать тестостерон

Как правильно пишется слово «тестостерон»

тестостеро́н

тестостеро́н, -а

Источник: Орфографический
академический ресурс «Академос» Института русского языка им. В.В. Виноградова РАН (словарная база
2020)

Делаем Карту слов лучше вместе

Привет! Меня зовут Лампобот, я компьютерная программа, которая помогает делать
Карту слов. Я отлично
умею считать, но пока плохо понимаю, как устроен ваш мир. Помоги мне разобраться!

Спасибо! Я стал чуточку лучше понимать мир эмоций.

Вопрос: заухать — это что-то нейтральное, положительное или отрицательное?

Ассоциации к слову «тестостерон»

Синонимы к слову «тестостерон»

Предложения со словом «тестостерон»

  • Потеря костной ткани у мужчин связана со снижением уровня тестостерона, а у женщин – со снижением уровня эстрогена.
  • Определяется это уровнем гормона тестостерона, которого у женщин намного меньше.
  • По мере развития сюжета становится понятно, что этот вопрос задаётся не от избытка тестостерона.
  • (все предложения)

Значение слова «тестостерон»

  • Тестостеро́н (от «тестикулы» и «стероид») — основной мужской половой гормон, андроген. Секретируется из холестерина клетками Лейдига семенников у мужчин, а также в небольших количествах яичниками у женщин и корой надпочечников и у мужчин, и у женщин. Является продуктом периферического метаболизма, отвечает за вирилизацию у мальчиков и андрогенизацию у девочек. (Википедия)

    Все значения слова ТЕСТОСТЕРОН

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Дополнительно

Источник

wordsonline.ru

Слова русского языка,
поиск и разбор слов онлайн

тестостерон

Правильно слово пишется: тестостерон

Всего в слове 11 букв, 4 гласных, 7 согласных, 4 слога.
Гласные: е, о, е, о;
Согласные: т, с, т, с, т, р, н.

Номера букв в слове

Номера букв в слове «тестостерон» в прямом и обратном порядке:

  • 11
    т
    1
  • 10
    е
    2
  • 9
    с
    3
  • 8
    т
    4
  • 7
    о
    5
  • 6
    с
    6
  • 5
    т
    7
  • 4
    е
    8
  • 3
    р
    9
  • 2
    о
    10
  • 1
    н
    11

Источник

Русский[править]

Морфологические и синтаксические свойства[править]

падеж ед. ч. мн. ч.
Им. тестостеро́н тестостеро́ны
Р. тестостеро́на тестостеро́нов
Д. тестостеро́ну тестостеро́нам
В. тестостеро́н тестостеро́ны
Тв. тестостеро́ном тестостеро́нами
Пр. тестостеро́не тестостеро́нах

тес—тос—те—ро́н

Существительное, неодушевлённое, мужской род, 2-е склонение (тип склонения 1a по классификации А. А. Зализняка).

Корень: -тестостерон-.

Произношение[править]

  • МФА: [tɛstəstɛˈron]

Семантические свойства[править]

Значение[править]

  1. биол., мед. основной мужской половой гормон ◆ Тестостерон против облысения ¶ Американские дерматологи Кристофер Папа и Альберт Клигмен сообщают об успешном применении мужского полового гормона тестостерона для борьбы с облысением. Новости отовсюду, 1966 г. // «Химия и жизнь» [НКРЯ] ◆ Интерстициальные эндокриноциты яичка выделяют мужской половой гормон тестостерон. Рудольф Самусев, Юрий Селин, «Анатомия человека», 2003 г. [НКРЯ] ◆ Мы просто-напросто свидетели «суеверной», как сказал поэт, «и угодливой любви пожилого человека». И в том-то и дело, что система несвободы в нашем любезном отечестве предоставляет ему полную свободу разрушать значимую вещь во имя остатков своего тестостерона. Анна Наринская, «В программе «Время Свободы — Итоги недели», 06 июня 2015 г. // «svoboda.org»

Синонимы[править]

  1. частичн.: андроген

Антонимы[править]

  1. эстрадиол, эстроген, эстрон

Гиперонимы[править]

  1. гормон

Гипонимы[править]

Родственные слова[править]

Ближайшее родство
  • прилагательные: тестостероновый

Этимология[править]

Происходит от греч. τεστοσ, из греч. τερόνη → лат. testiculus, досл. — мужское яичко.

Фразеологизмы и устойчивые сочетания[править]

Перевод[править]

Список переводов
  • Английскийen: testosterone

Библиография[править]

 Для улучшения этой статьи желательно:

  • Добавить все семантические связи (отсутствие можно указать прочерком, а неизвестность — символом вопроса)
Источник
Testosterone

The chemical structure of testosterone.
A ball-and-stick model of testosterone.
Names
IUPAC name

17β-Hydroxyandrost-4-en-3-one
Preferred IUPAC name

(1S,3aS,3bR,9aR,9bS,11aS)-1-Hydroxy-9a,11a-dimethyl-1,2,3,3a,3b,4,5,8,9,9a,9b,10,11,11a-tetradecahydro-7H-cyclopenta[a]phenanthren-7-one
Other names

Androst-4-en-17β-ol-3-one
Identifiers

CAS Number
  • 58-22-0 check

3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:17347 check
ChEMBL
  • ChEMBL386630 check
ChemSpider
  • 5791 check
DrugBank
  • DB00624 check
ECHA InfoCard 100.000.336 Edit this at Wikidata
EC Number
  • 200-370-5
KEGG
  • D00075 check

PubChem CID
  • 6013
UNII
  • 3XMK78S47O check

CompTox Dashboard (EPA)
  • DTXSID8022371 Edit this at Wikidata

InChI

  • InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 check

    Key: MUMGGOZAMZWBJJ-DYKIIFRCSA-N check

SMILES

  • O=C4C=C2/[C@]([C@H]1CC[C@@]3([C@@H](O)CC[C@H]3[C@@H]1CC2)C)(C)CC4
Properties

Chemical formula

 C19H28O2
Molar mass 288.431 g·mol−1
Melting point 151.0 °C (303.8 °F; 424.1 K)[1]
Pharmacology

ATC code

 G03BA03 (WHO)
License data
  • EU EMA: by INN

Routes of
administration

 Transdermal (gel, cream, solution, patch), by mouth (as testosterone undecanoate), in the cheek, intranasal (gel), intramuscular injection (as esters), subcutaneous pellets
Pharmacokinetics:

Bioavailability

 Oral: very low (due to extensive first pass metabolism)

Protein binding

 97.0–99.5% (to SHBG and albumin)[2]

Metabolism

 Liver (mainly reduction and conjugation)

Biological half-life

 30–45 minutes[citation needed]

Excretion

 Urine (90%), feces (6%)

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

check verify (what is check☒ ?)

Infobox references

Testosterone is the primary sex hormone and anabolic steroid in males.[3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.[4] In addition, testosterone in both sexes is involved in health and well-being, including moods, behaviour, and in the prevention of osteoporosis.[5][6] Insufficient levels of testosterone in men may lead to abnormalities including frailty and bone loss.

Testosterone is a steroid from the androstane class containing a ketone and a hydroxyl group at positions three and seventeen respectively. It is biosynthesized in several steps from cholesterol and is converted in the liver to inactive metabolites.[7] It exerts its action through binding to and activation of the androgen receptor.[7] In humans and most other vertebrates, testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females. On average, in adult males, levels of testosterone are about seven to eight times as great as in adult females.[8] As the metabolism of testosterone in males is more pronounced, the daily production is about 20 times greater in men.[9][10] Females are also more sensitive to the hormone.[11]

In addition to its role as a natural hormone, testosterone is used as a medication in the treatment of hypogonadism in men and breast cancer in women.[12] Since testosterone levels decrease as men age, testosterone is sometimes used in older men to counteract this deficiency. It is also used illicitly to enhance physique and performance, for instance in athletes.[13] The World Anti-Doping Agency is listing it as S1 Anabolic agent substance «prohibited at all times».[14]

Biological effects[edit]

In general, androgens such as testosterone promote protein synthesis and thus growth of tissues with androgen receptors.[15] Recently, Gharahdaghi et.al. reported that endogenous and exogenous testosterone play a permissive role in adaptation to exercise training in younger and older men.[16][17][18]Testosterone can be described as having virilising and anabolic effects (though these categorical descriptions are somewhat arbitrary, as there is a great deal of mutual overlap between them).[19]

  • Anabolic effects include growth of muscle mass and strength, increased bone density and strength, and stimulation of linear growth and bone maturation.
  • Androgenic effects include maturation of the sex organs, particularly the penis, and the formation of the scrotum in the fetus, and after birth (usually at puberty) a deepening of the voice, growth of facial hair (such as the beard) and axillary (underarm) hair. Many of these fall into the category of male secondary sex characteristics.

Testosterone effects can also be classified by the age of usual occurrence. For postnatal effects in both males and females, these are mostly dependent on the levels and duration of circulating free testosterone.[20]

Before birth[edit]

Effects before birth are divided into two categories, classified in relation to the stages of development.

The first period occurs between 4 and 6 weeks of the gestation. Examples include genital virilisation such as midline fusion, phallic urethra, scrotal thinning and rugation, and phallic enlargement; although the role of testosterone is far smaller than that of dihydrotestosterone. There is also development of the prostate gland and seminal vesicles.[citation needed]

During the second trimester, androgen level is associated with sex formation.[21] Specifically, testosterone, along with anti-Müllerian hormone (AMH) promote growth of the Wolffian duct and degeneration of the Müllerian duct respectively.[22] This period affects the femininization or masculinization of the fetus and can be a better predictor of feminine or masculine behaviours such as sex typed behaviour than an adult’s own levels. Prenatal androgens apparently influence interests and engagement in gendered activities and have moderate effects on spatial abilities.[23] Among women with congenital adrenal hyperplasia, a male-typical play in childhood correlated with reduced satisfaction with the female gender and reduced heterosexual interest in adulthood.[24]

Early infancy[edit]

Early infancy androgen effects are the least understood. In the first weeks of life for male infants, testosterone levels rise. The levels remain in a pubertal range for a few months, but usually reach the barely detectable levels of childhood by 4–7 months of age.[25][26] The function of this rise in humans is unknown. It has been theorized that brain masculinization is occurring since no significant changes have been identified in other parts of the body.[27] The male brain is masculinized by the aromatization of testosterone into estrogen, which crosses the blood–brain barrier and enters the male brain, whereas female fetuses have α-fetoprotein, which binds the estrogen so that female brains are not affected.[28]

Before puberty[edit]

Before puberty, effects of rising androgen levels occur in both boys and girls. These include adult-type body odor, increased oiliness of skin and hair, acne, pubarche (appearance of pubic hair), axillary hair (armpit hair), growth spurt, accelerated bone maturation, and facial hair.[29]

Pubertal[edit]

Pubertal effects begin to occur when androgen has been higher than normal adult female levels for months or years. In males, these are usual late pubertal effects, and occur in women after prolonged periods of heightened levels of free testosterone in the blood. The effects include:[29][30]

  • Growth of spermatogenic tissue in testicles, male fertility, penis or clitoris enlargement, increased libido and frequency of erection or clitoral engorgement occurs.
  • Growth of jaw, brow, chin, and nose and remodeling of facial bone contours, in conjunction with human growth hormone occurs.[31]
  • Completion of bone maturation and termination of growth. This occurs indirectly via estradiol metabolites and hence more gradually in men than women.
  • Increased muscle strength and mass, shoulders become broader and rib cage expands, deepening of voice, growth of the Adam’s apple.
  • Enlargement of sebaceous glands. This might cause acne, subcutaneous fat in face decreases.
  • Pubic hair extends to thighs and up toward umbilicus, development of facial hair (sideburns, beard, moustache), loss of scalp hair (androgenetic alopecia), increase in chest hair, periareolar hair, perianal hair, leg hair, armpit hair.

Adult[edit]

Testosterone is necessary for normal sperm development. It activates genes in Sertoli cells, which promote differentiation of spermatogonia. It regulates acute HPA (hypothalamic–pituitary–adrenal axis) response under dominance challenge.[32] Androgens including testosterone enhance muscle growth. Testosterone also regulates the population of thromboxane A2 receptors on megakaryocytes and platelets and hence platelet aggregation in humans.[33][34]

Adult testosterone effects are more clearly demonstrable in males than in females, but are likely important to both sexes. Some of these effects may decline as testosterone levels might decrease in the later decades of adult life.[35]

Health risks[edit]

Testosterone does not appear to increase the risk of developing prostate cancer. In people who have undergone testosterone deprivation therapy, testosterone increases beyond the castrate level have been shown to increase the rate of spread of an existing prostate cancer.[36][37][38]

Conflicting results have been obtained concerning the importance of testosterone in maintaining cardiovascular health.[39][40] Nevertheless, maintaining normal testosterone levels in elderly men has been shown to improve many parameters that are thought to reduce cardiovascular disease risk, such as increased lean body mass, decreased visceral fat mass, decreased total cholesterol, and glycemic control.[41]

High androgen levels are associated with menstrual cycle irregularities in both clinical populations and healthy women.[better source needed][42]

Sexual arousal[edit]

Testosterone levels follow a nycthemeral rhythm that peaks early each day, regardless of sexual activity.[43]

There are positive correlations between positive orgasm experience in women and testosterone levels where relaxation was a key perception of the experience. There is no correlation between testosterone and men’s perceptions of their orgasm experience, and also no correlation between higher testosterone levels and greater sexual assertiveness in either sex.[44]

Sexual arousal and masturbation in women produce small increases in testosterone concentrations.[45] The plasma levels of various steroids significantly increase after masturbation in men and the testosterone levels correlate to those levels.[46]

Mammalian studies[edit]

Studies conducted in rats have indicated that their degree of sexual arousal is sensitive to reductions in testosterone. When testosterone-deprived rats were given medium levels of testosterone, their sexual behaviours (copulation, partner preference, etc.) resumed, but not when given low amounts of the same hormone. Therefore, these mammals may provide a model for studying clinical populations among humans with sexual arousal deficits such as hypoactive sexual desire disorder.[47]

Every mammalian species examined demonstrated a marked increase in a male’s testosterone level upon encountering a novel female. The reflexive testosterone increases in male mice is related to the male’s initial level of sexual arousal.[48]

In non-human primates, it may be that testosterone in puberty stimulates sexual arousal, which allows the primate to increasingly seek out sexual experiences with females and thus creates a sexual preference for females.[49] Some research has also indicated that if testosterone is eliminated in an adult male human or other adult male primate’s system, its sexual motivation decreases, but there is no corresponding decrease in ability to engage in sexual activity (mounting, ejaculating, etc.).[49]

In accordance with sperm competition theory, testosterone levels are shown to increase as a response to previously neutral stimuli when conditioned to become sexual in male rats.[50] This reaction engages penile reflexes (such as erection and ejaculation) that aid in sperm competition when more than one male is present in mating encounters, allowing for more production of successful sperm and a higher chance of reproduction.

Males[edit]

In men, higher levels of testosterone are associated with periods of sexual activity.[51][52]

Men who watch a sexually explicit movie have an average increase of 35% in testosterone, peaking at 60–90 minutes after the end of the film, but no increase is seen in men who watch sexually neutral films.[53] Men who watch sexually explicit films also report increased motivation, competitiveness, and decreased exhaustion.[54] A link has also been found between relaxation following sexual arousal and testosterone levels.[55]

Men’s levels of testosterone change depending on whether they are exposed to an ovulating or nonovulating woman’s body odour. Men who are exposed to scents of ovulating women maintained a stable testosterone level that was higher than the testosterone level of men exposed to nonovulation cues. Men are heavily aware of hormone cycles in women.[56] This may be linked to the ovulatory shift hypothesis,[57] where males are adapted to respond to the ovulation cycles of females by sensing when they are most fertile and whereby females look for preferred male mates when they are the most fertile; both actions may be driven by hormones.

Females[edit]

Androgens may modulate the physiology of vaginal tissue and contribute to female genital sexual arousal.[58] Women’s level of testosterone is higher when measured pre-intercourse vs. pre-cuddling, as well as post-intercourse vs. post-cuddling.[59] There is a time lag effect when testosterone is administered, on genital arousal in women. In addition, a continuous increase in vaginal sexual arousal may result in higher genital sensations and sexual appetitive behaviors.[60]

When females have a higher baseline level of testosterone, they have higher increases in sexual arousal levels but smaller increases in testosterone, indicating a ceiling effect on testosterone levels in females. Sexual thoughts also change the level of testosterone but not the level of cortisol in the female body, and hormonal contraceptives may affect the variation in testosterone response to sexual thoughts.[61]

Testosterone may prove to be an effective treatment in female sexual arousal disorders,[62] and is available as a dermal patch. There is no FDA-approved androgen preparation for the treatment of androgen insufficiency; however, it has been used as an off-label use to treat low libido and sexual dysfunction in older women. Testosterone may be a treatment for postmenopausal women as long as they are effectively estrogenized.[62]

Romantic relationships[edit]

Falling in love has been linked with decreases in men’s testosterone levels while mixed changes are reported for women’s testosterone levels.[63]
[64]
There has been speculation that these changes in testosterone result in the temporary reduction of differences in behavior between the sexes.[64] However, the testosterone changes observed do not seem to be maintained as relationships develop over time.[63][64]

Men who produce less testosterone are more likely to be in a relationship[65] or married,[66] and men who produce more testosterone are more likely to divorce.[66] Marriage or commitment could cause a decrease in testosterone levels.[67] Single men who have not had relationship experience have lower testosterone levels than single men with experience. It is suggested that these single men with prior experience are in a more competitive state than their non-experienced counterparts.[68] Married men who engage in bond-maintenance activities such as spending the day with their spouse and/or child have no different testosterone levels compared to times when they do not engage in such activities. Collectively, these results suggest that the presence of competitive activities rather than bond-maintenance activities are more relevant to changes in testosterone levels.[69]

Men who produce more testosterone are more likely to engage in extramarital sex.[66] Testosterone levels do not rely on physical presence of a partner; testosterone levels of men engaging in same-city and long-distance relationships are similar.[65] Physical presence may be required for women who are in relationships for the testosterone–partner interaction, where same-city partnered women have lower testosterone levels than long-distance partnered women.[70]

Fatherhood[edit]

Fatherhood decreases testosterone levels in men, suggesting that the emotions and behaviour tied to decreased testosterone promote paternal care. In humans and other species that utilize allomaternal care, paternal investment in offspring is beneficial to said offspring’s survival because it allows the two parents to raise multiple children simultaneously. This increases the reproductive fitness of the parents because their offspring are more likely to survive and reproduce. Paternal care increases offspring survival due to increased access to higher quality food and reduced physical and immunological threats.[71] This is particularly beneficial for humans since offspring are dependent on parents for extended periods of time and mothers have relatively short inter-birth intervals.[72]

While the extent of paternal care varies between cultures, higher investment in direct child care has been seen to be correlated with lower average testosterone levels as well as temporary fluctuations.[73] For instance, fluctuation in testosterone levels when a child is in distress has been found to be indicative of fathering styles. If a father’s testosterone levels decrease in response to hearing their baby cry, it is an indication of empathizing with the baby. This is associated with increased nurturing behavior and better outcomes for the infant.[74]

Motivation[edit]

Testosterone levels play a major role in risk-taking during financial decisions.[75][76]

Aggression and criminality [edit]

Most studies support a link between adult criminality and testosterone. Nearly all studies of juvenile delinquency and testosterone are not significant. Most studies have also found testosterone to be associated with behaviors or personality traits linked with criminality such as antisocial behavior and alcoholism. Many studies have also been done on the relationship between more general aggressive behavior and feelings and testosterone. About half the studies have found a relationship and about half no relationship.[77] Studies have also found that testosterone facilitates aggression by modulating vasopressin receptors in the hypothalamus.[78]

There are two theories on the role of testosterone in aggression and competition.[79] The first one is the challenge hypothesis which states that testosterone would increase during puberty, thus facilitating reproductive and competitive behavior which would include aggression.[79] It is therefore the challenge of competition among males of the species that facilitates aggression and violence.[79] Studies conducted have found direct correlation between testosterone and dominance, especially among the most violent criminals in prison who had the highest testosterone levels.[79] The same research also found fathers (those outside competitive environments) had the lowest testosterone levels compared to other males.[79]

The second theory is similar and is known as «evolutionary neuroandrogenic (ENA) theory of male aggression».[80][81] Testosterone and other androgens have evolved to masculinize a brain in order to be competitive even to the point of risking harm to the person and others. By doing so, individuals with masculinized brains as a result of pre-natal and adult life testosterone and androgens enhance their resource acquiring abilities in order to survive, attract and copulate with mates as much as possible.[80] The masculinization of the brain is not just mediated by testosterone levels at the adult stage, but also testosterone exposure in the womb as a fetus. Higher pre-natal testosterone indicated by a low digit ratio as well as adult testosterone levels increased risk of fouls or aggression among male players in a soccer game.[82] Studies have also found higher pre-natal testosterone or lower digit ratio to be correlated with higher aggression in males.[83][84][85][86][87]

The rise in testosterone levels during competition predicted aggression in males but not in females.[88] Subjects who interacted with hand guns and an experimental game showed rise in testosterone and aggression.[89] Natural selection might have evolved males to be more sensitive to competitive and status challenge situations and that the interacting roles of testosterone are the essential ingredient for aggressive behaviour in these situations.[90] Testosterone mediates attraction to cruel and violent cues in men by promoting extended viewing of violent stimuli.[91] Testosterone-specific structural brain characteristic can predict aggressive behaviour in individuals.[92]

Testosterone might encourage fair behavior. For one study, subjects took part in a behavioral experiment where the distribution of a real amount of money was decided. The rules allowed both fair and unfair offers. The negotiating partner could subsequently accept or decline the offer. The fairer the offer, the less probable a refusal by the negotiating partner. If no agreement was reached, neither party earned anything. Test subjects with an artificially enhanced testosterone level generally made better, fairer offers than those who received placebos, thus reducing the risk of a rejection of their offer to a minimum. Two later studies have empirically confirmed these results.[93][94][95] However men with high testosterone were significantly 27% less generous in an ultimatum game.[96] The Annual NY Academy of Sciences has also found anabolic steroid use (which increases testosterone) to be higher in teenagers, and this was associated with increased violence.[97] Studies have also found administered testosterone to increase verbal aggression and anger in some participants.[98]

A few studies indicate that the testosterone derivative estradiol (one form of estrogen) might play an important role in male aggression.[77][99][100][101] Estradiol is known to correlate with aggression in male mice.[102] Moreover, the conversion of testosterone to estradiol regulates male aggression in sparrows during breeding season.[103] Rats who were given anabolic steroids that increase testosterone were also more physically aggressive to provocation as a result of «threat sensitivity».[104]

The relationship between testosterone and aggression may also function indirectly, as it has been proposed that testosterone does not amplify tendencies towards aggression but rather amplifies whatever tendencies will allow an individual to maintain social status when challenged. In most animals, aggression is the means of maintaining social status. However, humans have multiple ways of obtaining social status. This could explain why some studies find a link between testosterone and pro-social behaviour if pro-social behaviour is rewarded with social status. Thus the link between testosterone and aggression and violence is due to these being rewarded with social status.[105] The relationship may also be one of a «permissive effect» whereby testosterone does elevate aggression levels but only in the sense of allowing average aggression levels to be maintained; chemically or physically castrating the individual will reduce aggression levels (though it will not eliminate them) but the individual only needs a small-level of pre-castration testosterone to have aggression levels to return to normal, which they will remain at even if additional testosterone is added. Testosterone may also simply exaggerate or amplify existing aggression; for example, chimpanzees who receive testosterone increases become more aggressive to chimps lower than them in the social hierarchy but will still be submissive to chimps higher than them. Testosterone thus does not make the chimpanzee indiscriminately aggressive but instead amplifies his pre-existing aggression towards lower-ranked chimps.[106]

In humans, testosterone appears more to promote status-seeking and social dominance than simply increasing physical aggression. When controlling for the effects of belief in having received testosterone, women who have received testosterone make fairer offers than women who have not received testosterone.[107]

Brain[edit]

The brain is also affected by this sexual differentiation;[21] the enzyme aromatase converts testosterone into estradiol that is responsible for masculinization of the brain in male mice. In humans, masculinization of the fetal brain appears, by observation of gender preference in patients with congenital diseases of androgen formation or androgen receptor function, to be associated with functional androgen receptors.[108]

There are some differences between a male and female brain (possibly the result of different testosterone levels), one of them being size: the male human brain is, on average, larger.[109] Men were found to have a total myelinated fiber length of 176 000 km at the age of 20, whereas in women the total length was 149 000 km (approx. 15% less).[110]

No immediate short term effects on mood or behavior were found from the administration of supraphysiologic doses of testosterone for 10 weeks on 43 healthy men.[111] A correlation between testosterone and risk tolerance in career choice exists among women.[75][112]

Attention, memory, and spatial ability are key cognitive functions affected by testosterone in humans. Preliminary evidence suggests that low testosterone levels may be a risk factor for cognitive decline and possibly for dementia of the Alzheimer’s type,[113][114][115][116] a key argument in life extension medicine for the use of testosterone in anti-aging therapies. Much of the literature, however, suggests a curvilinear or even quadratic relationship between spatial performance and circulating testosterone,[117] where both hypo- and hypersecretion (deficient- and excessive-secretion) of circulating androgens have negative effects on cognition.

Immune system and inflammation[edit]

Testosterone deficiency is associated with an increased risk of metabolic syndrome, cardiovascular disease and mortality, which are also sequelae of chronic inflammation.[118] Testosterone plasma concentration inversely correlates to multiple biomarkers of inflammation including CRP, interleukin 1 beta, interleukin 6, TNF alpha and endotoxin concentration, as well as leukocyte count.[118] As demonstrated by a meta-analysis, substitution therapy with testosterone results in a significant reduction of inflammatory markers.[118] These effects are mediated by different mechanisms with synergistic action.[118] In androgen-deficient men with concomitant autoimmune thyroiditis, substitution therapy with testosterone leads to a decrease in thyroid autoantibody titres and an increase in thyroid’s secretory capacity (SPINA-GT).[119]

Medical use[edit]

Testosterone is used as a medication for the treatment of male hypogonadism, gender dysphoria, and certain types of breast cancer.[12][120] This is known as hormone replacement therapy (HRT) or testosterone replacement therapy (TRT), which maintains serum testosterone levels in the normal range. Decline of testosterone production with age has led to interest in androgen replacement therapy.[121] It is unclear if the use of testosterone for low levels due to aging is beneficial or harmful.[122]

Testosterone is included in the World Health Organization’s list of essential medicines, which are the most important medications needed in a basic health system.[123] It is available as a generic medication.[12] It can be administered as a cream or transdermal patch that is applied to the skin, by injection into a muscle, as a tablet that is placed in the cheek, or by ingestion.[12]

Common side effects from testosterone medication include acne, swelling, and breast enlargement in males.[12] Serious side effects may include liver toxicity, heart disease, and behavioral changes.[12] Women and children who are exposed may develop virilization.[12] It is recommended that individuals with prostate cancer not use the medication.[12] It can cause harm if used during pregnancy or breastfeeding.[12]

2020 guidelines from the American College of Physicians support the discussion of testosterone treatment in adult men with age-related low levels of testosterone who have sexual dysfunction. They recommend yearly evaluation regarding possible improvement and, if none, to discontinue testosterone; physicians should consider intramuscular treatments, rather than transdermal treatments, due to costs and since the effectiveness and harm of either method is similar. Testosterone treatment for reasons other than possible improvement of sexual dysfunction may not be recommended.[124][125]

Biological activity[edit]

Free testosterone[edit]

Lipophilic hormones (soluble in lipids but not in water), such as steroid hormones, including testosterone, are transported in water-based blood plasma through specific and non-specific proteins. Specific proteins include sex hormone-binding globulin (SHBG), which binds testosterone, dihydrotestosterone, estradiol, and other sex steroids. Non-specific binding proteins include albumin and lipoprotein. The part of the total hormone concentration that is not bound to its respective specific carrier protein is the free part. As a result, testosterone which is not bound to SHBG is called free testosterone. It seems that only the free amount of testosterone can bind to an androgenic receptor, which means they have biological activity.[126]

Steroid hormone activity[edit]

The effects of testosterone in humans and other vertebrates occur by way of multiple mechanisms: by activation of the androgen receptor (directly or as dihydrotestosterone), and by conversion to estradiol and activation of certain estrogen receptors.[127][128] Androgens such as testosterone have also been found to bind to and activate membrane androgen receptors.[129][130][131]

Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than testosterone, so that its androgenic potency is about 5 times that of T.[132] The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

Androgen receptors occur in many different vertebrate body system tissues, and both males and females respond similarly to similar levels. Greatly differing amounts of testosterone prenatally, at puberty, and throughout life account for a share of biological differences between males and females.

The bones and the brain are two important tissues in humans where the primary effect of testosterone is by way of aromatization to estradiol. In the bones, estradiol accelerates ossification of cartilage into bone, leading to closure of the epiphyses and conclusion of growth. In the central nervous system, testosterone is aromatized to estradiol. Estradiol rather than testosterone serves as the most important feedback signal to the hypothalamus (especially affecting LH secretion).[133][failed verification] In many mammals, prenatal or perinatal «masculinization» of the sexually dimorphic areas of the brain by estradiol derived from testosterone programs later male sexual behavior.[134]

Neurosteroid activity[edit]

Testosterone, via its active metabolite 3α-androstanediol, is a potent positive allosteric modulator of the GABAA receptor.[135]

Testosterone has been found to act as an antagonist of the TrkA and p75NTR, receptors for the neurotrophin nerve growth factor (NGF), with high affinity (around 5 nM).[136][137][138] In contrast to testosterone, DHEA and DHEA sulfate have been found to act as high-affinity agonists of these receptors.[136][137][138]

Testosterone is an antagonist of the sigma-1 receptor (Ki = 1,014 or 201 nM).[139] However, the concentrations of testosterone required for binding the receptor are far above even total circulating concentrations of testosterone in adult males (which range between 10 and 35 nM).[140]

Biochemistry[edit]

Biosynthesis[edit]

Like other steroid hormones, testosterone is derived from cholesterol (see figure).[142] The first step in the biosynthesis involves the oxidative cleavage of the side-chain of cholesterol by cholesterol side-chain cleavage enzyme (P450scc, CYP11A1), a mitochondrial cytochrome P450 oxidase with the loss of six carbon atoms to give pregnenolone. In the next step, two additional carbon atoms are removed by the CYP17A1 (17α-hydroxylase/17,20-lyase) enzyme in the endoplasmic reticulum to yield a variety of C19 steroids.[143] In addition, the 3β-hydroxyl group is oxidized by 3β-hydroxysteroid dehydrogenase to produce androstenedione. In the final and rate limiting step, the C17 keto group androstenedione is reduced by 17β-hydroxysteroid dehydrogenase to yield testosterone.

The largest amounts of testosterone (>95%) are produced by the testes in men,[4] while the adrenal glands account for most of the remainder. Testosterone is also synthesized in far smaller total quantities in women by the adrenal glands, thecal cells of the ovaries, and, during pregnancy, by the placenta.[144] In the testes, testosterone is produced by the Leydig cells.[145] The male generative glands also contain Sertoli cells, which require testosterone for spermatogenesis. Like most hormones, testosterone is supplied to target tissues in the blood where much of it is transported bound to a specific plasma protein, sex hormone-binding globulin (SHBG).

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Production rates, secretion rates, clearance rates, and blood levels of major sex hormones

Sex Sex hormone Reproductive
phase 		Blood
production rate 		Gonadal
secretion rate 		Metabolic
clearance rate 		Reference range (serum levels)
SI units Non-SI units
Men Androstenedione

–

 2.8 mg/day 1.6 mg/day 2200 L/day 2.8–7.3 nmol/L 80–210 ng/dL
Testosterone

–

 6.5 mg/day 6.2 mg/day 950 L/day 6.9–34.7 nmol/L 200–1000 ng/dL
Estrone

–

 150 μg/day 110 μg/day 2050 L/day 37–250 pmol/L 10–70 pg/mL
Estradiol

–

 60 μg/day 50 μg/day 1600 L/day <37–210 pmol/L 10–57 pg/mL
Estrone sulfate

–

 80 μg/day Insignificant 167 L/day 600–2500 pmol/L 200–900 pg/mL
Women Androstenedione

–

 3.2 mg/day 2.8 mg/day 2000 L/day 3.1–12.2 nmol/L 89–350 ng/dL
Testosterone

–

 190 μg/day 60 μg/day 500 L/day 0.7–2.8 nmol/L 20–81 ng/dL
Estrone Follicular phase 110 μg/day 80 μg/day 2200 L/day 110–400 pmol/L 30–110 pg/mL
Luteal phase 260 μg/day 150 μg/day 2200 L/day 310–660 pmol/L 80–180 pg/mL
Postmenopause 40 μg/day Insignificant 1610 L/day 22–230 pmol/L 6–60 pg/mL
Estradiol Follicular phase 90 μg/day 80 μg/day 1200 L/day <37–360 pmol/L 10–98 pg/mL
Luteal phase 250 μg/day 240 μg/day 1200 L/day 699–1250 pmol/L 190–341 pg/mL
Postmenopause 6 μg/day Insignificant 910 L/day <37–140 pmol/L 10–38 pg/mL
Estrone sulfate Follicular phase 100 μg/day Insignificant 146 L/day 700–3600 pmol/L 250–1300 pg/mL
Luteal phase 180 μg/day Insignificant 146 L/day 1100–7300 pmol/L 400–2600 pg/mL
Progesterone Follicular phase 2 mg/day 1.7 mg/day 2100 L/day 0.3–3 nmol/L 0.1–0.9 ng/mL
Luteal phase 25 mg/day 24 mg/day 2100 L/day 19–45 nmol/L 6–14 ng/mL

Notes and sources

Notes: «The concentration of a steroid in the circulation is determined by the rate at which it is secreted from glands, the rate of metabolism of precursor or prehormones into the steroid, and the rate at which it is extracted by tissues and metabolized. The secretion rate of a steroid refers to the total secretion of the compound from a gland per unit time. Secretion rates have been assessed by sampling the venous effluent from a gland over time and subtracting out the arterial and peripheral venous hormone concentration. The metabolic clearance rate of a steroid is defined as the volume of blood that has been completely cleared of the hormone per unit time. The production rate of a steroid hormone refers to entry into the blood of the compound from all possible sources, including secretion from glands and conversion of prohormones into the steroid of interest. At steady state, the amount of hormone entering the blood from all sources will be equal to the rate at which it is being cleared (metabolic clearance rate) multiplied by blood concentration (production rate = metabolic clearance rate × concentration). If there is little contribution of prohormone metabolism to the circulating pool of steroid, then the production rate will approximate the secretion rate.» Sources: See template.

Regulation[edit]

Hypothalamic–pituitary–testicular axis

In males, testosterone is synthesized primarily in Leydig cells. The number of Leydig cells in turn is regulated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In addition, the amount of testosterone produced by existing Leydig cells is under the control of LH, which regulates the expression of 17β-hydroxysteroid dehydrogenase.[146]

The amount of testosterone synthesized is regulated by the hypothalamic–pituitary–testicular axis (see figure to the right).[147] When testosterone levels are low, gonadotropin-releasing hormone (GnRH) is released by the hypothalamus, which in turn stimulates the pituitary gland to release FSH and LH. These latter two hormones stimulate the testis to synthesize testosterone. Finally, increasing levels of testosterone through a negative feedback loop act on the hypothalamus and pituitary to inhibit the release of GnRH and FSH/LH, respectively.

Factors affecting testosterone levels may include:

  • Age: Testosterone levels gradually reduce as men age.[148][149] This effect is sometimes referred to as andropause or late-onset hypogonadism.[150]
  • Exercise: Resistance training increases testosterone levels acutely,[151] however, in older men, that increase can be avoided by protein ingestion.[152] Endurance training in men may lead to lower testosterone levels.[153]
  • Nutrients: Vitamin A deficiency may lead to sub-optimal plasma testosterone levels.[154] The secosteroid vitamin D in levels of 400–1000 IU/d (10–25 µg/d) raises testosterone levels.[155] Zinc deficiency lowers testosterone levels[156] but over-supplementation has no effect on serum testosterone.[157] There is limited evidence that low-fat diets may reduce total and free testosterone levels in men,[158] and moderate evidence that short-term, very high protein diets (≥35% protein) decrease total testosterone levels in men.[159]
  • Weight loss: Reduction in weight may result in an increase in testosterone levels. Fat cells synthesize the enzyme aromatase, which converts testosterone, the male sex hormone, into estradiol, the female sex hormone.[160] However no clear association between body mass index and testosterone levels has been found.[161]
  • Miscellaneous: Sleep: (REM sleep) increases nocturnal testosterone levels.[162] Behavior: Dominance challenges can, in some cases, stimulate increased testosterone release in men.[163] Drugs: Natural or man-made antiandrogens including spearmint tea reduce testosterone levels.[164][165][166] Licorice can decrease the production of testosterone and this effect is greater in females.[167]

Distribution[edit]

The plasma protein binding of testosterone is 98.0 to 98.5%, with 1.5 to 2.0% free or unbound.[168] It is bound 65% to sex hormone-binding globulin (SHBG) and 33% bound weakly to albumin.[169]

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Plasma protein binding of testosterone and dihydrotestosterone

Compound Group Level (nM) Free (%) SHBG (%) CBG (%) Albumin (%)
Testosterone Adult men 23.0 2.23 44.3 3.56 49.9
Adult women
  Follicular phase 1.3 1.36 66.0 2.26 30.4
  Luteal phase 1.3 1.37 65.7 2.20 30.7
  Pregnancy 4.7 0.23 95.4 0.82 3.6
Dihydrotestosterone Adult men 1.70 0.88 49.7 0.22 39.2
Adult women
  Follicular phase 0.65 0.47 78.4 0.12 21.0
  Luteal phase 0.65 0.48 78.1 0.12 21.3
  Pregnancy 0.93 0.07 97.8 0.04 21.2
Sources: See template.

Metabolism[edit]

Both testosterone and 5α-DHT are metabolized mainly in the liver.[2][170] Approximately 50% of testosterone is metabolized via conjugation into testosterone glucuronide and to a lesser extent testosterone sulfate by glucuronosyltransferases and sulfotransferases, respectively.[2] An additional 40% of testosterone is metabolized in equal proportions into the 17-ketosteroids androsterone and etiocholanolone via the combined actions of 5α- and 5β-reductases, 3α-hydroxysteroid dehydrogenase, and 17β-HSD, in that order.[2][170][171] Androsterone and etiocholanolone are then glucuronidated and to a lesser extent sulfated similarly to testosterone.[2][170] The conjugates of testosterone and its hepatic metabolites are released from the liver into circulation and excreted in the urine and bile.[2][170][171] Only a small fraction (2%) of testosterone is excreted unchanged in the urine.[170]

In the hepatic 17-ketosteroid pathway of testosterone metabolism, testosterone is converted in the liver by 5α-reductase and 5β-reductase into 5α-DHT and the inactive 5β-DHT, respectively.[2][170] Then, 5α-DHT and 5β-DHT are converted by 3α-HSD into 3α-androstanediol and 3α-etiocholanediol, respectively.[2][170] Subsequently, 3α-androstanediol and 3α-etiocholanediol are converted by 17β-HSD into androsterone and etiocholanolone, which is followed by their conjugation and excretion.[2][170] 3β-Androstanediol and 3β-etiocholanediol can also be formed in this pathway when 5α-DHT and 5β-DHT are acted upon by 3β-HSD instead of 3α-HSD, respectively, and they can then be transformed into epiandrosterone and epietiocholanolone, respectively.[172][173] A small portion of approximately 3% of testosterone is reversibly converted in the liver into androstenedione by 17β-HSD.[171]

In addition to conjugation and the 17-ketosteroid pathway, testosterone can also be hydroxylated and oxidized in the liver by cytochrome P450 enzymes, including CYP3A4, CYP3A5, CYP2C9, CYP2C19, and CYP2D6.[174] 6β-Hydroxylation and to a lesser extent 16β-hydroxylation are the major transformations.[174] The 6β-hydroxylation of testosterone is catalyzed mainly by CYP3A4 and to a lesser extent CYP3A5 and is responsible for 75 to 80% of cytochrome P450-mediated testosterone metabolism.[174] In addition to 6β- and 16β-hydroxytestosterone, 1β-, 2α/β-, 11β-, and 15β-hydroxytestosterone are also formed as minor metabolites.[174][175] Certain cytochrome P450 enzymes such as CYP2C9 and CYP2C19 can also oxidize testosterone at the C17 position to form androstenedione.[174]

Two of the immediate metabolites of testosterone, 5α-DHT and estradiol, are biologically important and can be formed both in the liver and in extrahepatic tissues.[170] Approximately 5 to 7% of testosterone is converted by 5α-reductase into 5α-DHT, with circulating levels of 5α-DHT about 10% of those of testosterone, and approximately 0.3% of testosterone is converted into estradiol by aromatase.[4][170][176][177] 5α-Reductase is highly expressed in the male reproductive organs (including the prostate gland, seminal vesicles, and epididymides),[178] skin, hair follicles, and brain[179] and aromatase is highly expressed in adipose tissue, bone, and the brain.[180][181] As much as 90% of testosterone is converted into 5α-DHT in so-called androgenic tissues with high 5α-reductase expression,[171] and due to the several-fold greater potency of 5α-DHT as an AR agonist relative to testosterone,[182] it has been estimated that the effects of testosterone are potentiated 2- to 3-fold in such tissues.[183]

Levels[edit]

Total levels of testosterone in the body have been reported as 264 to 916 ng/dL (nanograms per deciliter) in non-obese European and American men age 19 to 39 years,[184] while mean testosterone levels in adult men have been reported as 630 ng/dL.[185] Although commonly used as a reference range,[186] some physicians have disputed the use of this range to determine hypogonadism.[187][188] Several professional medical groups have recommended that 350 ng/dl generally be considered the minimum normal level,[189] which is consistent with previous findings.[190][non-primary source needed][medical citation needed] Levels of testosterone in men decline with age.[184] In women, mean levels of total testosterone have been reported to be 32.6 ng/dL.[191][192] In women with hyperandrogenism, mean levels of total testosterone have been reported to be 62.1 ng/dL.[191][192]

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Testosterone levels in males and females

Total testosterone
Stage Age range Male Female
Values SI units Values SI units
Infant Premature (26–28 weeks) 59–125 ng/dL 2.047–4.337 nmol/L 5–16 ng/dL 0.173–0.555 nmol/L
Premature (31–35 weeks) 37–198 ng/dL 1.284–6.871 nmol/L 5–22 ng/dL 0.173–0.763 nmol/L
Newborn 75–400 ng/dL 2.602–13.877 nmol/L 20–64 ng/dL 0.694–2.220 nmol/L
Child 1–6 years ND ND ND ND
7–9 years 0–8 ng/dL 0–0.277 nmol/L 1–12 ng/dL 0.035–0.416 nmol/L
Just before puberty 3–10 ng/dL* 0.104–0.347 nmol/L* <10 ng/dL* <0.347 nmol/L*
Puberty 10–11 years 1–48 ng/dL 0.035–1.666 nmol/L 2–35 ng/dL 0.069–1.214 nmol/L
12–13 years 5–619 ng/dL 0.173–21.480 nmol/L 5–53 ng/dL 0.173–1.839 nmol/L
14–15 years 100–320 ng/dL 3.47–11.10 nmol/L 8–41 ng/dL 0.278–1.423 nmol/L
16–17 years 200–970 ng/dL* 6.94–33.66 nmol/L* 8–53 ng/dL 0.278–1.839 nmol/L
Adult ≥18 years 350–1080 ng/dL* 12.15–37.48 nmol/L* – –
20–39 years 400–1080 ng/dL 13.88–37.48 nmol/L – –
40–59 years 350–890 ng/dL 12.15–30.88 nmol/L – –
≥60 years 350–720 ng/dL 12.15–24.98 nmol/L – –
Premenopausal – – 10–54 ng/dL 0.347–1.873 nmol/L
Postmenopausal – – 7–40 ng/dL 0.243–1.388 nmol/L
Bioavailable testosterone
Stage Age range Male Female
Values SI units Values SI units
Child 1–6 years 0.2–1.3 ng/dL 0.007–0.045 nmol/L 0.2–1.3 ng/dL 0.007–0.045 nmol/L
7–9 years 0.2–2.3 ng/dL 0.007–0.079 nmol/L 0.2–4.2 ng/dL 0.007–0.146 nmol/L
Puberty 10–11 years 0.2–14.8 ng/dL 0.007–0.513 nmol/L 0.4–19.3 ng/dL 0.014–0.670 nmol/L
12–13 years 0.3–232.8 ng/dL 0.010–8.082 nmol/L 1.1–15.6 ng/dL 0.038–0.541 nmol/L
14–15 years 7.9–274.5 ng/dL 0.274–9.525 nmol/L 2.5–18.8 ng/dL 0.087–0.652 nmol/L
16–17 years 24.1–416.5 ng/dL 0.836–14.452 nmol/L 2.7–23.8 ng/dL 0.094–0.826 nmol/L
Adult ≥18 years ND ND – –
Premenopausal – – 1.9–22.8 ng/dL 0.066–0.791 nmol/L
Postmenopausal – – 1.6–19.1 ng/dL 0.055–0.662 nmol/L
Free testosterone
Stage Age range Male Female
Values SI units Values SI units
Child 1–6 years 0.1–0.6 pg/mL 0.3–2.1 pmol/L 0.1–0.6 pg/mL 0.3–2.1 pmol/L
7–9 years 0.1–0.8 pg/mL 0.3–2.8 pmol/L 0.1–1.6 pg/mL 0.3–5.6 pmol/L
Puberty 10–11 years 0.1–5.2 pg/mL 0.3–18.0 pmol/L 0.1–2.9 pg/mL 0.3–10.1 pmol/L
12–13 years 0.4–79.6 pg/mL 1.4–276.2 pmol/L 0.6–5.6 pg/mL 2.1–19.4 pmol/L
14–15 years 2.7–112.3 pg/mL 9.4–389.7 pmol/L 1.0–6.2 pg/mL 3.5–21.5 pmol/L
16–17 years 31.5–159 pg/mL 109.3–551.7 pmol/L 1.0–8.3 pg/mL 3.5–28.8 pmol/L
Adult ≥18 years 44–244 pg/mL 153–847 pmol/L – –
Premenopausal – – 0.8–9.2 pg/mL 2.8–31.9 pmol/L
Postmenopausal – – 0.6–6.7 pg/mL 2.1–23.2 pmol/L
Sources: See template.
Total testosterone levels in males throughout life

Life stage Tanner stage Age range Mean age Levels range Mean levels
Child Stage I <10 years – <30 ng/dL 5.8 ng/dL
Puberty Stage II 10–14 years 12 years <167 ng/dL 40 ng/dL
Stage III 12–16 years 13–14 years 21–719 ng/dL 190 ng/dL
Stage IV 13–17 years 14–15 years 25–912 ng/dL 370 ng/dL
Stage V 13–17 years 15 years 110–975 ng/dL 550 ng/dL
Adult – ≥18 years – 250–1,100 ng/dL 630 ng/dL
Sources: [193][194][185][195][196]

Measurement[edit]

Testosterone’s bioavailable concentration is commonly determined using the Vermeulen calculation or more precisely using the modified Vermeulen method,[197][198] which considers the dimeric form of sex-hormone-binding-globulin.[199]

Both methods use chemical equilibrium to derive the concentration of bioavailable testosterone: in circulation, testosterone has two major binding partners, albumin (weakly bound) and sex-hormone-binding-globulin (strongly bound). These methods are described in detail in the accompanying figure.

  • Dimeric sex-hormone-binding-globulin with its testosterone ligands

    Dimeric sex-hormone-binding-globulin with its testosterone ligands

  • Two methods for determining the concentration of bioavailable testosterone.

    Two methods for determining the concentration of bioavailable testosterone.

History[edit]

Nobel Prize winner, Leopold Ruzicka of Ciba, a pharmaceutical industry giant that synthesized testosterone

A testicular action was linked to circulating blood fractions – now understood to be a family of androgenic hormones – in the early work on castration and testicular transplantation in fowl by Arnold Adolph Berthold (1803–1861).[200] Research on the action of testosterone received a brief boost in 1889, when the Harvard professor Charles-Édouard Brown-Séquard (1817–1894), then in Paris, self-injected subcutaneously a «rejuvenating elixir» consisting of an extract of dog and guinea pig testicle. He reported in The Lancet that his vigor and feeling of well-being were markedly restored but the effects were transient,[201] and Brown-Séquard’s hopes for the compound were dashed. Suffering the ridicule of his colleagues, he abandoned his work on the mechanisms and effects of androgens in human beings.

In 1927, the University of Chicago’s Professor of Physiologic Chemistry, Fred C. Koch, established easy access to a large source of bovine testicles – the Chicago stockyards – and recruited students willing to endure the tedious work of extracting their isolates. In that year, Koch and his student, Lemuel McGee, derived 20 mg of a substance from a supply of 40 pounds of bovine testicles that, when administered to castrated roosters, pigs and rats, re-masculinized them.[202] The group of Ernst Laqueur at the University of Amsterdam purified testosterone from bovine testicles in a similar manner in 1934, but the isolation of the hormone from animal tissues in amounts permitting serious study in humans was not feasible until three European pharmaceutical giants – Schering (Berlin, Germany), Organon (Oss, Netherlands) and Ciba (Basel, Switzerland) – began full-scale steroid research and development programs in the 1930s.

The Organon group in the Netherlands were the first to isolate the hormone, identified in a May 1935 paper «On Crystalline Male Hormone from Testicles (Testosterone)».[203] They named the hormone testosterone, from the stems of testicle and sterol, and the suffix of ketone. The structure was worked out by Schering’s Adolf Butenandt, at the Chemisches Institut of Technical University in Gdańsk.[204][205]

The chemical synthesis of testosterone from cholesterol was achieved in August that year by Butenandt and Hanisch.[206] Only a week later, the Ciba group in Zurich, Leopold Ruzicka (1887–1976) and A. Wettstein, published their synthesis of testosterone.[207] These independent partial syntheses of testosterone from a cholesterol base earned both Butenandt and Ruzicka the joint 1939 Nobel Prize in Chemistry.[205][208] Testosterone was identified as 17β-hydroxyandrost-4-en-3-one (C19H28O2), a solid polycyclic alcohol with a hydroxyl group at the 17th carbon atom. This also made it obvious that additional modifications on the synthesized testosterone could be made, i.e., esterification and alkylation.

The partial synthesis in the 1930s of abundant, potent testosterone esters permitted the characterization of the hormone’s effects, so that Kochakian and Murlin (1936) were able to show that testosterone raised nitrogen retention (a mechanism central to anabolism) in the dog, after which Allan Kenyon’s group[209] was able to demonstrate both anabolic and androgenic effects of testosterone propionate in eunuchoidal men, boys, and women. The period of the early 1930s to the 1950s has been called «The Golden Age of Steroid Chemistry»,[210] and work during this period progressed quickly.[211]

Other species[edit]

Testosterone is observed in most vertebrates. Testosterone and the classical nuclear androgen receptor first appeared in gnathostomes (jawed vertebrates).[212] Agnathans (jawless vertebrates) such as lampreys do not produce testosterone but instead use androstenedione as a male sex hormone.[213] Fish make a slightly different form called 11-ketotestosterone.[214] Its counterpart in insects is ecdysone.[215] The presence of these ubiquitous steroids in a wide range of animals suggest that sex hormones have an ancient evolutionary history.[216]

See also[edit]

  • List of androgens/anabolic steroids
  • List of human hormones

References[edit]

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  9. ^ Southren AL, Gordon GG, Tochimoto S, Pinzon G, Lane DR, Stypulkowski W (May 1967). «Mean plasma concentration, metabolic clearance and basal plasma production rates of testosterone in normal young men and women using a constant infusion procedure: effect of time of day and plasma concentration on the metabolic clearance rate of testosterone». The Journal of Clinical Endocrinology & Metabolism. 27 (5): 686–94. doi:10.1210/jcem-27-5-686. PMID 6025472.
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  205. ^ a b Freeman ER, Bloom DA, McGuire EJ (February 2001). «A brief history of testosterone». The Journal of Urology. 165 (2): 371–73. doi:10.1097/00005392-200102000-00004. PMID 11176375.
  206. ^ Butenandt A, Hanisch G (1935). «Uber die Umwandlung des Dehydroandrosterons in Androstenol-(17)-one-(3) (Testosterone); um Weg zur Darstellung des Testosterons auf Cholesterin (Vorlauf Mitteilung). [The conversion of dehydroandrosterone into androstenol-(17)-one-3 (testosterone); a method for the production of testosterone from cholesterol (preliminary communication)]». Chemische Berichte (in German). 68 (9): 1859–62. doi:10.1002/cber.19350680937.
  207. ^ Ruzicka L, Wettstein A (1935). «Uber die kristallinische Herstellung des Testikelhormons, Testosteron (Androsten-3-ol-17-ol) [The crystalline production of the testicle hormone, testosterone (Androsten-3-ol-17-ol)]». Helvetica Chimica Acta (in German). 18: 1264–75. doi:10.1002/hlca.193501801176.
  208. ^ Hoberman JM, Yesalis CE (February 1995). «The history of synthetic testosterone». Scientific American. 272 (2): 76–81. Bibcode:1995SciAm.272b..76H. doi:10.1038/scientificamerican0295-76. PMID 7817189.
  209. ^ Kenyon AT, Knowlton K, Sandiford I, Koch FC, Lotwin, G (February 1940). «A comparative study of the metabolic effects of testosterone propionate in normal men and women and in eunuchoidism». Endocrinology. 26 (1): 26–45. doi:10.1210/Endo-26-1-26.
  210. ^ Schwarz S, Onken D, Schubert A (July 1999). «The steroid story of Jenapharm: from the late 1940s to the early 1970s». Steroids. 64 (7): 439–45. doi:10.1016/S0039-128X(99)00003-3. PMID 10443899. S2CID 40156824.
  211. ^ de Kruif P (1945). The Male Hormone. New York: Harcourt, Brace.
  212. ^ Guerriero G (2009). «Vertebrate sex steroid receptors: evolution, ligands, and neurodistribution». Annals of the New York Academy of Sciences. 1163 (1): 154–68. Bibcode:2009NYASA1163..154G. doi:10.1111/j.1749-6632.2009.04460.x. PMID 19456336. S2CID 5790990.
  213. ^ Bryan MB, Scott AP, Li W (2008). «Sex steroids and their receptors in lampreys». Steroids. 73 (1): 1–12. doi:10.1016/j.steroids.2007.08.011. PMID 17931674. S2CID 33753909.
  214. ^ Nelson RF (2005). An introduction to behavioral endocrinology. Sunderland, Mass: Sinauer Associates. p. 143. ISBN 978-0-87893-617-5.
  215. ^ De Loof A (October 2006). «Ecdysteroids: the overlooked sex steroids of insects? Males: the black box». Insect Science. 13 (5): 325–338. doi:10.1111/j.1744-7917.2006.00101.x. S2CID 221810929.
  216. ^ Mechoulam R, Brueggemeier RW, Denlinger DL (September 1984). «Estrogens in insects». Cellular and Molecular Life Sciences. 40 (9): 942–44. doi:10.1007/BF01946450. S2CID 31950471.

Further reading[edit]

  • Fargo KN, Pak TR, Foecking EM, Jones KJ (2010). «Molecular Biology of Androgen Action: Perspectives on Neuroprotective and Neurotherapeutic Effects.». In Pfaff DW, Etgen AM (eds.). Molecular Mechanisms of Hormone Actions on Behavior. Elsevier Inc. pp. 1219–1246. doi:10.1016/B978-008088783-8.00036-X. ISBN 978-0-12-374939-0.
  • Dowd NE (2013). «Sperm, testosterone, masculinities and fatherhood». Nevada Law Journal. 13 (2): 8.
  • Celec P, Ostatníková D, Hodosy J (February 2015). «On the effects of testosterone on brain behavioral functions». Frontiers in Neuroscience. 9: 12. doi:10.3389/fnins.2015.00012. PMC 4330791. PMID 25741229.
Источник
Testosterone

The chemical structure of testosterone.
A ball-and-stick model of testosterone.
Names
IUPAC name

17β-Hydroxyandrost-4-en-3-one
Preferred IUPAC name

(1S,3aS,3bR,9aR,9bS,11aS)-1-Hydroxy-9a,11a-dimethyl-1,2,3,3a,3b,4,5,8,9,9a,9b,10,11,11a-tetradecahydro-7H-cyclopenta[a]phenanthren-7-one
Other names

Androst-4-en-17β-ol-3-one
Identifiers

CAS Number
  • 58-22-0 check

3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:17347 check
ChEMBL
  • ChEMBL386630 check
ChemSpider
  • 5791 check
DrugBank
  • DB00624 check
ECHA InfoCard 100.000.336 Edit this at Wikidata
EC Number
  • 200-370-5
KEGG
  • D00075 check

PubChem CID
  • 6013
UNII
  • 3XMK78S47O check

CompTox Dashboard (EPA)
  • DTXSID8022371 Edit this at Wikidata

InChI

  • InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 check

    Key: MUMGGOZAMZWBJJ-DYKIIFRCSA-N check

SMILES

  • O=C4C=C2/[C@]([C@H]1CC[C@@]3([C@@H](O)CC[C@H]3[C@@H]1CC2)C)(C)CC4
Properties

Chemical formula

 C19H28O2
Molar mass 288.431 g·mol−1
Melting point 151.0 °C (303.8 °F; 424.1 K)[1]
Pharmacology

ATC code

 G03BA03 (WHO)
License data
  • EU EMA: by INN

Routes of
administration

 Transdermal (gel, cream, solution, patch), by mouth (as testosterone undecanoate), in the cheek, intranasal (gel), intramuscular injection (as esters), subcutaneous pellets
Pharmacokinetics:

Bioavailability

 Oral: very low (due to extensive first pass metabolism)

Protein binding

 97.0–99.5% (to SHBG and albumin)[2]

Metabolism

 Liver (mainly reduction and conjugation)

Biological half-life

 30–45 minutes[citation needed]

Excretion

 Urine (90%), feces (6%)

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

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Infobox references

Testosterone is the primary sex hormone and anabolic steroid in males.[3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.[4] In addition, testosterone in both sexes is involved in health and well-being, including moods, behaviour, and in the prevention of osteoporosis.[5][6] Insufficient levels of testosterone in men may lead to abnormalities including frailty and bone loss.

Testosterone is a steroid from the androstane class containing a ketone and a hydroxyl group at positions three and seventeen respectively. It is biosynthesized in several steps from cholesterol and is converted in the liver to inactive metabolites.[7] It exerts its action through binding to and activation of the androgen receptor.[7] In humans and most other vertebrates, testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females. On average, in adult males, levels of testosterone are about seven to eight times as great as in adult females.[8] As the metabolism of testosterone in males is more pronounced, the daily production is about 20 times greater in men.[9][10] Females are also more sensitive to the hormone.[11]

In addition to its role as a natural hormone, testosterone is used as a medication in the treatment of hypogonadism in men and breast cancer in women.[12] Since testosterone levels decrease as men age, testosterone is sometimes used in older men to counteract this deficiency. It is also used illicitly to enhance physique and performance, for instance in athletes.[13] The World Anti-Doping Agency is listing it as S1 Anabolic agent substance «prohibited at all times».[14]

Biological effects[edit]

In general, androgens such as testosterone promote protein synthesis and thus growth of tissues with androgen receptors.[15] Recently, Gharahdaghi et.al. reported that endogenous and exogenous testosterone play a permissive role in adaptation to exercise training in younger and older men.[16][17][18]Testosterone can be described as having virilising and anabolic effects (though these categorical descriptions are somewhat arbitrary, as there is a great deal of mutual overlap between them).[19]

  • Anabolic effects include growth of muscle mass and strength, increased bone density and strength, and stimulation of linear growth and bone maturation.
  • Androgenic effects include maturation of the sex organs, particularly the penis, and the formation of the scrotum in the fetus, and after birth (usually at puberty) a deepening of the voice, growth of facial hair (such as the beard) and axillary (underarm) hair. Many of these fall into the category of male secondary sex characteristics.

Testosterone effects can also be classified by the age of usual occurrence. For postnatal effects in both males and females, these are mostly dependent on the levels and duration of circulating free testosterone.[20]

Before birth[edit]

Effects before birth are divided into two categories, classified in relation to the stages of development.

The first period occurs between 4 and 6 weeks of the gestation. Examples include genital virilisation such as midline fusion, phallic urethra, scrotal thinning and rugation, and phallic enlargement; although the role of testosterone is far smaller than that of dihydrotestosterone. There is also development of the prostate gland and seminal vesicles.[citation needed]

During the second trimester, androgen level is associated with sex formation.[21] Specifically, testosterone, along with anti-Müllerian hormone (AMH) promote growth of the Wolffian duct and degeneration of the Müllerian duct respectively.[22] This period affects the femininization or masculinization of the fetus and can be a better predictor of feminine or masculine behaviours such as sex typed behaviour than an adult’s own levels. Prenatal androgens apparently influence interests and engagement in gendered activities and have moderate effects on spatial abilities.[23] Among women with congenital adrenal hyperplasia, a male-typical play in childhood correlated with reduced satisfaction with the female gender and reduced heterosexual interest in adulthood.[24]

Early infancy[edit]

Early infancy androgen effects are the least understood. In the first weeks of life for male infants, testosterone levels rise. The levels remain in a pubertal range for a few months, but usually reach the barely detectable levels of childhood by 4–7 months of age.[25][26] The function of this rise in humans is unknown. It has been theorized that brain masculinization is occurring since no significant changes have been identified in other parts of the body.[27] The male brain is masculinized by the aromatization of testosterone into estrogen, which crosses the blood–brain barrier and enters the male brain, whereas female fetuses have α-fetoprotein, which binds the estrogen so that female brains are not affected.[28]

Before puberty[edit]

Before puberty, effects of rising androgen levels occur in both boys and girls. These include adult-type body odor, increased oiliness of skin and hair, acne, pubarche (appearance of pubic hair), axillary hair (armpit hair), growth spurt, accelerated bone maturation, and facial hair.[29]

Pubertal[edit]

Pubertal effects begin to occur when androgen has been higher than normal adult female levels for months or years. In males, these are usual late pubertal effects, and occur in women after prolonged periods of heightened levels of free testosterone in the blood. The effects include:[29][30]

  • Growth of spermatogenic tissue in testicles, male fertility, penis or clitoris enlargement, increased libido and frequency of erection or clitoral engorgement occurs.
  • Growth of jaw, brow, chin, and nose and remodeling of facial bone contours, in conjunction with human growth hormone occurs.[31]
  • Completion of bone maturation and termination of growth. This occurs indirectly via estradiol metabolites and hence more gradually in men than women.
  • Increased muscle strength and mass, shoulders become broader and rib cage expands, deepening of voice, growth of the Adam’s apple.
  • Enlargement of sebaceous glands. This might cause acne, subcutaneous fat in face decreases.
  • Pubic hair extends to thighs and up toward umbilicus, development of facial hair (sideburns, beard, moustache), loss of scalp hair (androgenetic alopecia), increase in chest hair, periareolar hair, perianal hair, leg hair, armpit hair.

Adult[edit]

Testosterone is necessary for normal sperm development. It activates genes in Sertoli cells, which promote differentiation of spermatogonia. It regulates acute HPA (hypothalamic–pituitary–adrenal axis) response under dominance challenge.[32] Androgens including testosterone enhance muscle growth. Testosterone also regulates the population of thromboxane A2 receptors on megakaryocytes and platelets and hence platelet aggregation in humans.[33][34]

Adult testosterone effects are more clearly demonstrable in males than in females, but are likely important to both sexes. Some of these effects may decline as testosterone levels might decrease in the later decades of adult life.[35]

Health risks[edit]

Testosterone does not appear to increase the risk of developing prostate cancer. In people who have undergone testosterone deprivation therapy, testosterone increases beyond the castrate level have been shown to increase the rate of spread of an existing prostate cancer.[36][37][38]

Conflicting results have been obtained concerning the importance of testosterone in maintaining cardiovascular health.[39][40] Nevertheless, maintaining normal testosterone levels in elderly men has been shown to improve many parameters that are thought to reduce cardiovascular disease risk, such as increased lean body mass, decreased visceral fat mass, decreased total cholesterol, and glycemic control.[41]

High androgen levels are associated with menstrual cycle irregularities in both clinical populations and healthy women.[better source needed][42]

Sexual arousal[edit]

Testosterone levels follow a nycthemeral rhythm that peaks early each day, regardless of sexual activity.[43]

There are positive correlations between positive orgasm experience in women and testosterone levels where relaxation was a key perception of the experience. There is no correlation between testosterone and men’s perceptions of their orgasm experience, and also no correlation between higher testosterone levels and greater sexual assertiveness in either sex.[44]

Sexual arousal and masturbation in women produce small increases in testosterone concentrations.[45] The plasma levels of various steroids significantly increase after masturbation in men and the testosterone levels correlate to those levels.[46]

Mammalian studies[edit]

Studies conducted in rats have indicated that their degree of sexual arousal is sensitive to reductions in testosterone. When testosterone-deprived rats were given medium levels of testosterone, their sexual behaviours (copulation, partner preference, etc.) resumed, but not when given low amounts of the same hormone. Therefore, these mammals may provide a model for studying clinical populations among humans with sexual arousal deficits such as hypoactive sexual desire disorder.[47]

Every mammalian species examined demonstrated a marked increase in a male’s testosterone level upon encountering a novel female. The reflexive testosterone increases in male mice is related to the male’s initial level of sexual arousal.[48]

In non-human primates, it may be that testosterone in puberty stimulates sexual arousal, which allows the primate to increasingly seek out sexual experiences with females and thus creates a sexual preference for females.[49] Some research has also indicated that if testosterone is eliminated in an adult male human or other adult male primate’s system, its sexual motivation decreases, but there is no corresponding decrease in ability to engage in sexual activity (mounting, ejaculating, etc.).[49]

In accordance with sperm competition theory, testosterone levels are shown to increase as a response to previously neutral stimuli when conditioned to become sexual in male rats.[50] This reaction engages penile reflexes (such as erection and ejaculation) that aid in sperm competition when more than one male is present in mating encounters, allowing for more production of successful sperm and a higher chance of reproduction.

Males[edit]

In men, higher levels of testosterone are associated with periods of sexual activity.[51][52]

Men who watch a sexually explicit movie have an average increase of 35% in testosterone, peaking at 60–90 minutes after the end of the film, but no increase is seen in men who watch sexually neutral films.[53] Men who watch sexually explicit films also report increased motivation, competitiveness, and decreased exhaustion.[54] A link has also been found between relaxation following sexual arousal and testosterone levels.[55]

Men’s levels of testosterone change depending on whether they are exposed to an ovulating or nonovulating woman’s body odour. Men who are exposed to scents of ovulating women maintained a stable testosterone level that was higher than the testosterone level of men exposed to nonovulation cues. Men are heavily aware of hormone cycles in women.[56] This may be linked to the ovulatory shift hypothesis,[57] where males are adapted to respond to the ovulation cycles of females by sensing when they are most fertile and whereby females look for preferred male mates when they are the most fertile; both actions may be driven by hormones.

Females[edit]

Androgens may modulate the physiology of vaginal tissue and contribute to female genital sexual arousal.[58] Women’s level of testosterone is higher when measured pre-intercourse vs. pre-cuddling, as well as post-intercourse vs. post-cuddling.[59] There is a time lag effect when testosterone is administered, on genital arousal in women. In addition, a continuous increase in vaginal sexual arousal may result in higher genital sensations and sexual appetitive behaviors.[60]

When females have a higher baseline level of testosterone, they have higher increases in sexual arousal levels but smaller increases in testosterone, indicating a ceiling effect on testosterone levels in females. Sexual thoughts also change the level of testosterone but not the level of cortisol in the female body, and hormonal contraceptives may affect the variation in testosterone response to sexual thoughts.[61]

Testosterone may prove to be an effective treatment in female sexual arousal disorders,[62] and is available as a dermal patch. There is no FDA-approved androgen preparation for the treatment of androgen insufficiency; however, it has been used as an off-label use to treat low libido and sexual dysfunction in older women. Testosterone may be a treatment for postmenopausal women as long as they are effectively estrogenized.[62]

Romantic relationships[edit]

Falling in love has been linked with decreases in men’s testosterone levels while mixed changes are reported for women’s testosterone levels.[63]
[64]
There has been speculation that these changes in testosterone result in the temporary reduction of differences in behavior between the sexes.[64] However, the testosterone changes observed do not seem to be maintained as relationships develop over time.[63][64]

Men who produce less testosterone are more likely to be in a relationship[65] or married,[66] and men who produce more testosterone are more likely to divorce.[66] Marriage or commitment could cause a decrease in testosterone levels.[67] Single men who have not had relationship experience have lower testosterone levels than single men with experience. It is suggested that these single men with prior experience are in a more competitive state than their non-experienced counterparts.[68] Married men who engage in bond-maintenance activities such as spending the day with their spouse and/or child have no different testosterone levels compared to times when they do not engage in such activities. Collectively, these results suggest that the presence of competitive activities rather than bond-maintenance activities are more relevant to changes in testosterone levels.[69]

Men who produce more testosterone are more likely to engage in extramarital sex.[66] Testosterone levels do not rely on physical presence of a partner; testosterone levels of men engaging in same-city and long-distance relationships are similar.[65] Physical presence may be required for women who are in relationships for the testosterone–partner interaction, where same-city partnered women have lower testosterone levels than long-distance partnered women.[70]

Fatherhood[edit]

Fatherhood decreases testosterone levels in men, suggesting that the emotions and behaviour tied to decreased testosterone promote paternal care. In humans and other species that utilize allomaternal care, paternal investment in offspring is beneficial to said offspring’s survival because it allows the two parents to raise multiple children simultaneously. This increases the reproductive fitness of the parents because their offspring are more likely to survive and reproduce. Paternal care increases offspring survival due to increased access to higher quality food and reduced physical and immunological threats.[71] This is particularly beneficial for humans since offspring are dependent on parents for extended periods of time and mothers have relatively short inter-birth intervals.[72]

While the extent of paternal care varies between cultures, higher investment in direct child care has been seen to be correlated with lower average testosterone levels as well as temporary fluctuations.[73] For instance, fluctuation in testosterone levels when a child is in distress has been found to be indicative of fathering styles. If a father’s testosterone levels decrease in response to hearing their baby cry, it is an indication of empathizing with the baby. This is associated with increased nurturing behavior and better outcomes for the infant.[74]

Motivation[edit]

Testosterone levels play a major role in risk-taking during financial decisions.[75][76]

Aggression and criminality [edit]

Most studies support a link between adult criminality and testosterone. Nearly all studies of juvenile delinquency and testosterone are not significant. Most studies have also found testosterone to be associated with behaviors or personality traits linked with criminality such as antisocial behavior and alcoholism. Many studies have also been done on the relationship between more general aggressive behavior and feelings and testosterone. About half the studies have found a relationship and about half no relationship.[77] Studies have also found that testosterone facilitates aggression by modulating vasopressin receptors in the hypothalamus.[78]

There are two theories on the role of testosterone in aggression and competition.[79] The first one is the challenge hypothesis which states that testosterone would increase during puberty, thus facilitating reproductive and competitive behavior which would include aggression.[79] It is therefore the challenge of competition among males of the species that facilitates aggression and violence.[79] Studies conducted have found direct correlation between testosterone and dominance, especially among the most violent criminals in prison who had the highest testosterone levels.[79] The same research also found fathers (those outside competitive environments) had the lowest testosterone levels compared to other males.[79]

The second theory is similar and is known as «evolutionary neuroandrogenic (ENA) theory of male aggression».[80][81] Testosterone and other androgens have evolved to masculinize a brain in order to be competitive even to the point of risking harm to the person and others. By doing so, individuals with masculinized brains as a result of pre-natal and adult life testosterone and androgens enhance their resource acquiring abilities in order to survive, attract and copulate with mates as much as possible.[80] The masculinization of the brain is not just mediated by testosterone levels at the adult stage, but also testosterone exposure in the womb as a fetus. Higher pre-natal testosterone indicated by a low digit ratio as well as adult testosterone levels increased risk of fouls or aggression among male players in a soccer game.[82] Studies have also found higher pre-natal testosterone or lower digit ratio to be correlated with higher aggression in males.[83][84][85][86][87]

The rise in testosterone levels during competition predicted aggression in males but not in females.[88] Subjects who interacted with hand guns and an experimental game showed rise in testosterone and aggression.[89] Natural selection might have evolved males to be more sensitive to competitive and status challenge situations and that the interacting roles of testosterone are the essential ingredient for aggressive behaviour in these situations.[90] Testosterone mediates attraction to cruel and violent cues in men by promoting extended viewing of violent stimuli.[91] Testosterone-specific structural brain characteristic can predict aggressive behaviour in individuals.[92]

Testosterone might encourage fair behavior. For one study, subjects took part in a behavioral experiment where the distribution of a real amount of money was decided. The rules allowed both fair and unfair offers. The negotiating partner could subsequently accept or decline the offer. The fairer the offer, the less probable a refusal by the negotiating partner. If no agreement was reached, neither party earned anything. Test subjects with an artificially enhanced testosterone level generally made better, fairer offers than those who received placebos, thus reducing the risk of a rejection of their offer to a minimum. Two later studies have empirically confirmed these results.[93][94][95] However men with high testosterone were significantly 27% less generous in an ultimatum game.[96] The Annual NY Academy of Sciences has also found anabolic steroid use (which increases testosterone) to be higher in teenagers, and this was associated with increased violence.[97] Studies have also found administered testosterone to increase verbal aggression and anger in some participants.[98]

A few studies indicate that the testosterone derivative estradiol (one form of estrogen) might play an important role in male aggression.[77][99][100][101] Estradiol is known to correlate with aggression in male mice.[102] Moreover, the conversion of testosterone to estradiol regulates male aggression in sparrows during breeding season.[103] Rats who were given anabolic steroids that increase testosterone were also more physically aggressive to provocation as a result of «threat sensitivity».[104]

The relationship between testosterone and aggression may also function indirectly, as it has been proposed that testosterone does not amplify tendencies towards aggression but rather amplifies whatever tendencies will allow an individual to maintain social status when challenged. In most animals, aggression is the means of maintaining social status. However, humans have multiple ways of obtaining social status. This could explain why some studies find a link between testosterone and pro-social behaviour if pro-social behaviour is rewarded with social status. Thus the link between testosterone and aggression and violence is due to these being rewarded with social status.[105] The relationship may also be one of a «permissive effect» whereby testosterone does elevate aggression levels but only in the sense of allowing average aggression levels to be maintained; chemically or physically castrating the individual will reduce aggression levels (though it will not eliminate them) but the individual only needs a small-level of pre-castration testosterone to have aggression levels to return to normal, which they will remain at even if additional testosterone is added. Testosterone may also simply exaggerate or amplify existing aggression; for example, chimpanzees who receive testosterone increases become more aggressive to chimps lower than them in the social hierarchy but will still be submissive to chimps higher than them. Testosterone thus does not make the chimpanzee indiscriminately aggressive but instead amplifies his pre-existing aggression towards lower-ranked chimps.[106]

In humans, testosterone appears more to promote status-seeking and social dominance than simply increasing physical aggression. When controlling for the effects of belief in having received testosterone, women who have received testosterone make fairer offers than women who have not received testosterone.[107]

Brain[edit]

The brain is also affected by this sexual differentiation;[21] the enzyme aromatase converts testosterone into estradiol that is responsible for masculinization of the brain in male mice. In humans, masculinization of the fetal brain appears, by observation of gender preference in patients with congenital diseases of androgen formation or androgen receptor function, to be associated with functional androgen receptors.[108]

There are some differences between a male and female brain (possibly the result of different testosterone levels), one of them being size: the male human brain is, on average, larger.[109] Men were found to have a total myelinated fiber length of 176 000 km at the age of 20, whereas in women the total length was 149 000 km (approx. 15% less).[110]

No immediate short term effects on mood or behavior were found from the administration of supraphysiologic doses of testosterone for 10 weeks on 43 healthy men.[111] A correlation between testosterone and risk tolerance in career choice exists among women.[75][112]

Attention, memory, and spatial ability are key cognitive functions affected by testosterone in humans. Preliminary evidence suggests that low testosterone levels may be a risk factor for cognitive decline and possibly for dementia of the Alzheimer’s type,[113][114][115][116] a key argument in life extension medicine for the use of testosterone in anti-aging therapies. Much of the literature, however, suggests a curvilinear or even quadratic relationship between spatial performance and circulating testosterone,[117] where both hypo- and hypersecretion (deficient- and excessive-secretion) of circulating androgens have negative effects on cognition.

Immune system and inflammation[edit]

Testosterone deficiency is associated with an increased risk of metabolic syndrome, cardiovascular disease and mortality, which are also sequelae of chronic inflammation.[118] Testosterone plasma concentration inversely correlates to multiple biomarkers of inflammation including CRP, interleukin 1 beta, interleukin 6, TNF alpha and endotoxin concentration, as well as leukocyte count.[118] As demonstrated by a meta-analysis, substitution therapy with testosterone results in a significant reduction of inflammatory markers.[118] These effects are mediated by different mechanisms with synergistic action.[118] In androgen-deficient men with concomitant autoimmune thyroiditis, substitution therapy with testosterone leads to a decrease in thyroid autoantibody titres and an increase in thyroid’s secretory capacity (SPINA-GT).[119]

Medical use[edit]

Testosterone is used as a medication for the treatment of male hypogonadism, gender dysphoria, and certain types of breast cancer.[12][120] This is known as hormone replacement therapy (HRT) or testosterone replacement therapy (TRT), which maintains serum testosterone levels in the normal range. Decline of testosterone production with age has led to interest in androgen replacement therapy.[121] It is unclear if the use of testosterone for low levels due to aging is beneficial or harmful.[122]

Testosterone is included in the World Health Organization’s list of essential medicines, which are the most important medications needed in a basic health system.[123] It is available as a generic medication.[12] It can be administered as a cream or transdermal patch that is applied to the skin, by injection into a muscle, as a tablet that is placed in the cheek, or by ingestion.[12]

Common side effects from testosterone medication include acne, swelling, and breast enlargement in males.[12] Serious side effects may include liver toxicity, heart disease, and behavioral changes.[12] Women and children who are exposed may develop virilization.[12] It is recommended that individuals with prostate cancer not use the medication.[12] It can cause harm if used during pregnancy or breastfeeding.[12]

2020 guidelines from the American College of Physicians support the discussion of testosterone treatment in adult men with age-related low levels of testosterone who have sexual dysfunction. They recommend yearly evaluation regarding possible improvement and, if none, to discontinue testosterone; physicians should consider intramuscular treatments, rather than transdermal treatments, due to costs and since the effectiveness and harm of either method is similar. Testosterone treatment for reasons other than possible improvement of sexual dysfunction may not be recommended.[124][125]

Biological activity[edit]

Free testosterone[edit]

Lipophilic hormones (soluble in lipids but not in water), such as steroid hormones, including testosterone, are transported in water-based blood plasma through specific and non-specific proteins. Specific proteins include sex hormone-binding globulin (SHBG), which binds testosterone, dihydrotestosterone, estradiol, and other sex steroids. Non-specific binding proteins include albumin and lipoprotein. The part of the total hormone concentration that is not bound to its respective specific carrier protein is the free part. As a result, testosterone which is not bound to SHBG is called free testosterone. It seems that only the free amount of testosterone can bind to an androgenic receptor, which means they have biological activity.[126]

Steroid hormone activity[edit]

The effects of testosterone in humans and other vertebrates occur by way of multiple mechanisms: by activation of the androgen receptor (directly or as dihydrotestosterone), and by conversion to estradiol and activation of certain estrogen receptors.[127][128] Androgens such as testosterone have also been found to bind to and activate membrane androgen receptors.[129][130][131]

Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than testosterone, so that its androgenic potency is about 5 times that of T.[132] The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

Androgen receptors occur in many different vertebrate body system tissues, and both males and females respond similarly to similar levels. Greatly differing amounts of testosterone prenatally, at puberty, and throughout life account for a share of biological differences between males and females.

The bones and the brain are two important tissues in humans where the primary effect of testosterone is by way of aromatization to estradiol. In the bones, estradiol accelerates ossification of cartilage into bone, leading to closure of the epiphyses and conclusion of growth. In the central nervous system, testosterone is aromatized to estradiol. Estradiol rather than testosterone serves as the most important feedback signal to the hypothalamus (especially affecting LH secretion).[133][failed verification] In many mammals, prenatal or perinatal «masculinization» of the sexually dimorphic areas of the brain by estradiol derived from testosterone programs later male sexual behavior.[134]

Neurosteroid activity[edit]

Testosterone, via its active metabolite 3α-androstanediol, is a potent positive allosteric modulator of the GABAA receptor.[135]

Testosterone has been found to act as an antagonist of the TrkA and p75NTR, receptors for the neurotrophin nerve growth factor (NGF), with high affinity (around 5 nM).[136][137][138] In contrast to testosterone, DHEA and DHEA sulfate have been found to act as high-affinity agonists of these receptors.[136][137][138]

Testosterone is an antagonist of the sigma-1 receptor (Ki = 1,014 or 201 nM).[139] However, the concentrations of testosterone required for binding the receptor are far above even total circulating concentrations of testosterone in adult males (which range between 10 and 35 nM).[140]

Biochemistry[edit]

Biosynthesis[edit]

Like other steroid hormones, testosterone is derived from cholesterol (see figure).[142] The first step in the biosynthesis involves the oxidative cleavage of the side-chain of cholesterol by cholesterol side-chain cleavage enzyme (P450scc, CYP11A1), a mitochondrial cytochrome P450 oxidase with the loss of six carbon atoms to give pregnenolone. In the next step, two additional carbon atoms are removed by the CYP17A1 (17α-hydroxylase/17,20-lyase) enzyme in the endoplasmic reticulum to yield a variety of C19 steroids.[143] In addition, the 3β-hydroxyl group is oxidized by 3β-hydroxysteroid dehydrogenase to produce androstenedione. In the final and rate limiting step, the C17 keto group androstenedione is reduced by 17β-hydroxysteroid dehydrogenase to yield testosterone.

The largest amounts of testosterone (>95%) are produced by the testes in men,[4] while the adrenal glands account for most of the remainder. Testosterone is also synthesized in far smaller total quantities in women by the adrenal glands, thecal cells of the ovaries, and, during pregnancy, by the placenta.[144] In the testes, testosterone is produced by the Leydig cells.[145] The male generative glands also contain Sertoli cells, which require testosterone for spermatogenesis. Like most hormones, testosterone is supplied to target tissues in the blood where much of it is transported bound to a specific plasma protein, sex hormone-binding globulin (SHBG).

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Production rates, secretion rates, clearance rates, and blood levels of major sex hormones

Sex Sex hormone Reproductive
phase 		Blood
production rate 		Gonadal
secretion rate 		Metabolic
clearance rate 		Reference range (serum levels)
SI units Non-SI units
Men Androstenedione

–

 2.8 mg/day 1.6 mg/day 2200 L/day 2.8–7.3 nmol/L 80–210 ng/dL
Testosterone

–

 6.5 mg/day 6.2 mg/day 950 L/day 6.9–34.7 nmol/L 200–1000 ng/dL
Estrone

–

 150 μg/day 110 μg/day 2050 L/day 37–250 pmol/L 10–70 pg/mL
Estradiol

–

 60 μg/day 50 μg/day 1600 L/day <37–210 pmol/L 10–57 pg/mL
Estrone sulfate

–

 80 μg/day Insignificant 167 L/day 600–2500 pmol/L 200–900 pg/mL
Women Androstenedione

–

 3.2 mg/day 2.8 mg/day 2000 L/day 3.1–12.2 nmol/L 89–350 ng/dL
Testosterone

–

 190 μg/day 60 μg/day 500 L/day 0.7–2.8 nmol/L 20–81 ng/dL
Estrone Follicular phase 110 μg/day 80 μg/day 2200 L/day 110–400 pmol/L 30–110 pg/mL
Luteal phase 260 μg/day 150 μg/day 2200 L/day 310–660 pmol/L 80–180 pg/mL
Postmenopause 40 μg/day Insignificant 1610 L/day 22–230 pmol/L 6–60 pg/mL
Estradiol Follicular phase 90 μg/day 80 μg/day 1200 L/day <37–360 pmol/L 10–98 pg/mL
Luteal phase 250 μg/day 240 μg/day 1200 L/day 699–1250 pmol/L 190–341 pg/mL
Postmenopause 6 μg/day Insignificant 910 L/day <37–140 pmol/L 10–38 pg/mL
Estrone sulfate Follicular phase 100 μg/day Insignificant 146 L/day 700–3600 pmol/L 250–1300 pg/mL
Luteal phase 180 μg/day Insignificant 146 L/day 1100–7300 pmol/L 400–2600 pg/mL
Progesterone Follicular phase 2 mg/day 1.7 mg/day 2100 L/day 0.3–3 nmol/L 0.1–0.9 ng/mL
Luteal phase 25 mg/day 24 mg/day 2100 L/day 19–45 nmol/L 6–14 ng/mL

Notes and sources

Notes: «The concentration of a steroid in the circulation is determined by the rate at which it is secreted from glands, the rate of metabolism of precursor or prehormones into the steroid, and the rate at which it is extracted by tissues and metabolized. The secretion rate of a steroid refers to the total secretion of the compound from a gland per unit time. Secretion rates have been assessed by sampling the venous effluent from a gland over time and subtracting out the arterial and peripheral venous hormone concentration. The metabolic clearance rate of a steroid is defined as the volume of blood that has been completely cleared of the hormone per unit time. The production rate of a steroid hormone refers to entry into the blood of the compound from all possible sources, including secretion from glands and conversion of prohormones into the steroid of interest. At steady state, the amount of hormone entering the blood from all sources will be equal to the rate at which it is being cleared (metabolic clearance rate) multiplied by blood concentration (production rate = metabolic clearance rate × concentration). If there is little contribution of prohormone metabolism to the circulating pool of steroid, then the production rate will approximate the secretion rate.» Sources: See template.

Regulation[edit]

Hypothalamic–pituitary–testicular axis

In males, testosterone is synthesized primarily in Leydig cells. The number of Leydig cells in turn is regulated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In addition, the amount of testosterone produced by existing Leydig cells is under the control of LH, which regulates the expression of 17β-hydroxysteroid dehydrogenase.[146]

The amount of testosterone synthesized is regulated by the hypothalamic–pituitary–testicular axis (see figure to the right).[147] When testosterone levels are low, gonadotropin-releasing hormone (GnRH) is released by the hypothalamus, which in turn stimulates the pituitary gland to release FSH and LH. These latter two hormones stimulate the testis to synthesize testosterone. Finally, increasing levels of testosterone through a negative feedback loop act on the hypothalamus and pituitary to inhibit the release of GnRH and FSH/LH, respectively.

Factors affecting testosterone levels may include:

  • Age: Testosterone levels gradually reduce as men age.[148][149] This effect is sometimes referred to as andropause or late-onset hypogonadism.[150]
  • Exercise: Resistance training increases testosterone levels acutely,[151] however, in older men, that increase can be avoided by protein ingestion.[152] Endurance training in men may lead to lower testosterone levels.[153]
  • Nutrients: Vitamin A deficiency may lead to sub-optimal plasma testosterone levels.[154] The secosteroid vitamin D in levels of 400–1000 IU/d (10–25 µg/d) raises testosterone levels.[155] Zinc deficiency lowers testosterone levels[156] but over-supplementation has no effect on serum testosterone.[157] There is limited evidence that low-fat diets may reduce total and free testosterone levels in men,[158] and moderate evidence that short-term, very high protein diets (≥35% protein) decrease total testosterone levels in men.[159]
  • Weight loss: Reduction in weight may result in an increase in testosterone levels. Fat cells synthesize the enzyme aromatase, which converts testosterone, the male sex hormone, into estradiol, the female sex hormone.[160] However no clear association between body mass index and testosterone levels has been found.[161]
  • Miscellaneous: Sleep: (REM sleep) increases nocturnal testosterone levels.[162] Behavior: Dominance challenges can, in some cases, stimulate increased testosterone release in men.[163] Drugs: Natural or man-made antiandrogens including spearmint tea reduce testosterone levels.[164][165][166] Licorice can decrease the production of testosterone and this effect is greater in females.[167]

Distribution[edit]

The plasma protein binding of testosterone is 98.0 to 98.5%, with 1.5 to 2.0% free or unbound.[168] It is bound 65% to sex hormone-binding globulin (SHBG) and 33% bound weakly to albumin.[169]

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Plasma protein binding of testosterone and dihydrotestosterone

Compound Group Level (nM) Free (%) SHBG (%) CBG (%) Albumin (%)
Testosterone Adult men 23.0 2.23 44.3 3.56 49.9
Adult women
  Follicular phase 1.3 1.36 66.0 2.26 30.4
  Luteal phase 1.3 1.37 65.7 2.20 30.7
  Pregnancy 4.7 0.23 95.4 0.82 3.6
Dihydrotestosterone Adult men 1.70 0.88 49.7 0.22 39.2
Adult women
  Follicular phase 0.65 0.47 78.4 0.12 21.0
  Luteal phase 0.65 0.48 78.1 0.12 21.3
  Pregnancy 0.93 0.07 97.8 0.04 21.2
Sources: See template.

Metabolism[edit]

Both testosterone and 5α-DHT are metabolized mainly in the liver.[2][170] Approximately 50% of testosterone is metabolized via conjugation into testosterone glucuronide and to a lesser extent testosterone sulfate by glucuronosyltransferases and sulfotransferases, respectively.[2] An additional 40% of testosterone is metabolized in equal proportions into the 17-ketosteroids androsterone and etiocholanolone via the combined actions of 5α- and 5β-reductases, 3α-hydroxysteroid dehydrogenase, and 17β-HSD, in that order.[2][170][171] Androsterone and etiocholanolone are then glucuronidated and to a lesser extent sulfated similarly to testosterone.[2][170] The conjugates of testosterone and its hepatic metabolites are released from the liver into circulation and excreted in the urine and bile.[2][170][171] Only a small fraction (2%) of testosterone is excreted unchanged in the urine.[170]

In the hepatic 17-ketosteroid pathway of testosterone metabolism, testosterone is converted in the liver by 5α-reductase and 5β-reductase into 5α-DHT and the inactive 5β-DHT, respectively.[2][170] Then, 5α-DHT and 5β-DHT are converted by 3α-HSD into 3α-androstanediol and 3α-etiocholanediol, respectively.[2][170] Subsequently, 3α-androstanediol and 3α-etiocholanediol are converted by 17β-HSD into androsterone and etiocholanolone, which is followed by their conjugation and excretion.[2][170] 3β-Androstanediol and 3β-etiocholanediol can also be formed in this pathway when 5α-DHT and 5β-DHT are acted upon by 3β-HSD instead of 3α-HSD, respectively, and they can then be transformed into epiandrosterone and epietiocholanolone, respectively.[172][173] A small portion of approximately 3% of testosterone is reversibly converted in the liver into androstenedione by 17β-HSD.[171]

In addition to conjugation and the 17-ketosteroid pathway, testosterone can also be hydroxylated and oxidized in the liver by cytochrome P450 enzymes, including CYP3A4, CYP3A5, CYP2C9, CYP2C19, and CYP2D6.[174] 6β-Hydroxylation and to a lesser extent 16β-hydroxylation are the major transformations.[174] The 6β-hydroxylation of testosterone is catalyzed mainly by CYP3A4 and to a lesser extent CYP3A5 and is responsible for 75 to 80% of cytochrome P450-mediated testosterone metabolism.[174] In addition to 6β- and 16β-hydroxytestosterone, 1β-, 2α/β-, 11β-, and 15β-hydroxytestosterone are also formed as minor metabolites.[174][175] Certain cytochrome P450 enzymes such as CYP2C9 and CYP2C19 can also oxidize testosterone at the C17 position to form androstenedione.[174]

Two of the immediate metabolites of testosterone, 5α-DHT and estradiol, are biologically important and can be formed both in the liver and in extrahepatic tissues.[170] Approximately 5 to 7% of testosterone is converted by 5α-reductase into 5α-DHT, with circulating levels of 5α-DHT about 10% of those of testosterone, and approximately 0.3% of testosterone is converted into estradiol by aromatase.[4][170][176][177] 5α-Reductase is highly expressed in the male reproductive organs (including the prostate gland, seminal vesicles, and epididymides),[178] skin, hair follicles, and brain[179] and aromatase is highly expressed in adipose tissue, bone, and the brain.[180][181] As much as 90% of testosterone is converted into 5α-DHT in so-called androgenic tissues with high 5α-reductase expression,[171] and due to the several-fold greater potency of 5α-DHT as an AR agonist relative to testosterone,[182] it has been estimated that the effects of testosterone are potentiated 2- to 3-fold in such tissues.[183]

Levels[edit]

Total levels of testosterone in the body have been reported as 264 to 916 ng/dL (nanograms per deciliter) in non-obese European and American men age 19 to 39 years,[184] while mean testosterone levels in adult men have been reported as 630 ng/dL.[185] Although commonly used as a reference range,[186] some physicians have disputed the use of this range to determine hypogonadism.[187][188] Several professional medical groups have recommended that 350 ng/dl generally be considered the minimum normal level,[189] which is consistent with previous findings.[190][non-primary source needed][medical citation needed] Levels of testosterone in men decline with age.[184] In women, mean levels of total testosterone have been reported to be 32.6 ng/dL.[191][192] In women with hyperandrogenism, mean levels of total testosterone have been reported to be 62.1 ng/dL.[191][192]

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Testosterone levels in males and females

Total testosterone
Stage Age range Male Female
Values SI units Values SI units
Infant Premature (26–28 weeks) 59–125 ng/dL 2.047–4.337 nmol/L 5–16 ng/dL 0.173–0.555 nmol/L
Premature (31–35 weeks) 37–198 ng/dL 1.284–6.871 nmol/L 5–22 ng/dL 0.173–0.763 nmol/L
Newborn 75–400 ng/dL 2.602–13.877 nmol/L 20–64 ng/dL 0.694–2.220 nmol/L
Child 1–6 years ND ND ND ND
7–9 years 0–8 ng/dL 0–0.277 nmol/L 1–12 ng/dL 0.035–0.416 nmol/L
Just before puberty 3–10 ng/dL* 0.104–0.347 nmol/L* <10 ng/dL* <0.347 nmol/L*
Puberty 10–11 years 1–48 ng/dL 0.035–1.666 nmol/L 2–35 ng/dL 0.069–1.214 nmol/L
12–13 years 5–619 ng/dL 0.173–21.480 nmol/L 5–53 ng/dL 0.173–1.839 nmol/L
14–15 years 100–320 ng/dL 3.47–11.10 nmol/L 8–41 ng/dL 0.278–1.423 nmol/L
16–17 years 200–970 ng/dL* 6.94–33.66 nmol/L* 8–53 ng/dL 0.278–1.839 nmol/L
Adult ≥18 years 350–1080 ng/dL* 12.15–37.48 nmol/L* – –
20–39 years 400–1080 ng/dL 13.88–37.48 nmol/L – –
40–59 years 350–890 ng/dL 12.15–30.88 nmol/L – –
≥60 years 350–720 ng/dL 12.15–24.98 nmol/L – –
Premenopausal – – 10–54 ng/dL 0.347–1.873 nmol/L
Postmenopausal – – 7–40 ng/dL 0.243–1.388 nmol/L
Bioavailable testosterone
Stage Age range Male Female
Values SI units Values SI units
Child 1–6 years 0.2–1.3 ng/dL 0.007–0.045 nmol/L 0.2–1.3 ng/dL 0.007–0.045 nmol/L
7–9 years 0.2–2.3 ng/dL 0.007–0.079 nmol/L 0.2–4.2 ng/dL 0.007–0.146 nmol/L
Puberty 10–11 years 0.2–14.8 ng/dL 0.007–0.513 nmol/L 0.4–19.3 ng/dL 0.014–0.670 nmol/L
12–13 years 0.3–232.8 ng/dL 0.010–8.082 nmol/L 1.1–15.6 ng/dL 0.038–0.541 nmol/L
14–15 years 7.9–274.5 ng/dL 0.274–9.525 nmol/L 2.5–18.8 ng/dL 0.087–0.652 nmol/L
16–17 years 24.1–416.5 ng/dL 0.836–14.452 nmol/L 2.7–23.8 ng/dL 0.094–0.826 nmol/L
Adult ≥18 years ND ND – –
Premenopausal – – 1.9–22.8 ng/dL 0.066–0.791 nmol/L
Postmenopausal – – 1.6–19.1 ng/dL 0.055–0.662 nmol/L
Free testosterone
Stage Age range Male Female
Values SI units Values SI units
Child 1–6 years 0.1–0.6 pg/mL 0.3–2.1 pmol/L 0.1–0.6 pg/mL 0.3–2.1 pmol/L
7–9 years 0.1–0.8 pg/mL 0.3–2.8 pmol/L 0.1–1.6 pg/mL 0.3–5.6 pmol/L
Puberty 10–11 years 0.1–5.2 pg/mL 0.3–18.0 pmol/L 0.1–2.9 pg/mL 0.3–10.1 pmol/L
12–13 years 0.4–79.6 pg/mL 1.4–276.2 pmol/L 0.6–5.6 pg/mL 2.1–19.4 pmol/L
14–15 years 2.7–112.3 pg/mL 9.4–389.7 pmol/L 1.0–6.2 pg/mL 3.5–21.5 pmol/L
16–17 years 31.5–159 pg/mL 109.3–551.7 pmol/L 1.0–8.3 pg/mL 3.5–28.8 pmol/L
Adult ≥18 years 44–244 pg/mL 153–847 pmol/L – –
Premenopausal – – 0.8–9.2 pg/mL 2.8–31.9 pmol/L
Postmenopausal – – 0.6–6.7 pg/mL 2.1–23.2 pmol/L
Sources: See template.
Total testosterone levels in males throughout life

Life stage Tanner stage Age range Mean age Levels range Mean levels
Child Stage I <10 years – <30 ng/dL 5.8 ng/dL
Puberty Stage II 10–14 years 12 years <167 ng/dL 40 ng/dL
Stage III 12–16 years 13–14 years 21–719 ng/dL 190 ng/dL
Stage IV 13–17 years 14–15 years 25–912 ng/dL 370 ng/dL
Stage V 13–17 years 15 years 110–975 ng/dL 550 ng/dL
Adult – ≥18 years – 250–1,100 ng/dL 630 ng/dL
Sources: [193][194][185][195][196]

Measurement[edit]

Testosterone’s bioavailable concentration is commonly determined using the Vermeulen calculation or more precisely using the modified Vermeulen method,[197][198] which considers the dimeric form of sex-hormone-binding-globulin.[199]

Both methods use chemical equilibrium to derive the concentration of bioavailable testosterone: in circulation, testosterone has two major binding partners, albumin (weakly bound) and sex-hormone-binding-globulin (strongly bound). These methods are described in detail in the accompanying figure.

  • Dimeric sex-hormone-binding-globulin with its testosterone ligands

    Dimeric sex-hormone-binding-globulin with its testosterone ligands

  • Two methods for determining the concentration of bioavailable testosterone.

    Two methods for determining the concentration of bioavailable testosterone.

History[edit]

Nobel Prize winner, Leopold Ruzicka of Ciba, a pharmaceutical industry giant that synthesized testosterone

A testicular action was linked to circulating blood fractions – now understood to be a family of androgenic hormones – in the early work on castration and testicular transplantation in fowl by Arnold Adolph Berthold (1803–1861).[200] Research on the action of testosterone received a brief boost in 1889, when the Harvard professor Charles-Édouard Brown-Séquard (1817–1894), then in Paris, self-injected subcutaneously a «rejuvenating elixir» consisting of an extract of dog and guinea pig testicle. He reported in The Lancet that his vigor and feeling of well-being were markedly restored but the effects were transient,[201] and Brown-Séquard’s hopes for the compound were dashed. Suffering the ridicule of his colleagues, he abandoned his work on the mechanisms and effects of androgens in human beings.

In 1927, the University of Chicago’s Professor of Physiologic Chemistry, Fred C. Koch, established easy access to a large source of bovine testicles – the Chicago stockyards – and recruited students willing to endure the tedious work of extracting their isolates. In that year, Koch and his student, Lemuel McGee, derived 20 mg of a substance from a supply of 40 pounds of bovine testicles that, when administered to castrated roosters, pigs and rats, re-masculinized them.[202] The group of Ernst Laqueur at the University of Amsterdam purified testosterone from bovine testicles in a similar manner in 1934, but the isolation of the hormone from animal tissues in amounts permitting serious study in humans was not feasible until three European pharmaceutical giants – Schering (Berlin, Germany), Organon (Oss, Netherlands) and Ciba (Basel, Switzerland) – began full-scale steroid research and development programs in the 1930s.

The Organon group in the Netherlands were the first to isolate the hormone, identified in a May 1935 paper «On Crystalline Male Hormone from Testicles (Testosterone)».[203] They named the hormone testosterone, from the stems of testicle and sterol, and the suffix of ketone. The structure was worked out by Schering’s Adolf Butenandt, at the Chemisches Institut of Technical University in Gdańsk.[204][205]

The chemical synthesis of testosterone from cholesterol was achieved in August that year by Butenandt and Hanisch.[206] Only a week later, the Ciba group in Zurich, Leopold Ruzicka (1887–1976) and A. Wettstein, published their synthesis of testosterone.[207] These independent partial syntheses of testosterone from a cholesterol base earned both Butenandt and Ruzicka the joint 1939 Nobel Prize in Chemistry.[205][208] Testosterone was identified as 17β-hydroxyandrost-4-en-3-one (C19H28O2), a solid polycyclic alcohol with a hydroxyl group at the 17th carbon atom. This also made it obvious that additional modifications on the synthesized testosterone could be made, i.e., esterification and alkylation.

The partial synthesis in the 1930s of abundant, potent testosterone esters permitted the characterization of the hormone’s effects, so that Kochakian and Murlin (1936) were able to show that testosterone raised nitrogen retention (a mechanism central to anabolism) in the dog, after which Allan Kenyon’s group[209] was able to demonstrate both anabolic and androgenic effects of testosterone propionate in eunuchoidal men, boys, and women. The period of the early 1930s to the 1950s has been called «The Golden Age of Steroid Chemistry»,[210] and work during this period progressed quickly.[211]

Other species[edit]

Testosterone is observed in most vertebrates. Testosterone and the classical nuclear androgen receptor first appeared in gnathostomes (jawed vertebrates).[212] Agnathans (jawless vertebrates) such as lampreys do not produce testosterone but instead use androstenedione as a male sex hormone.[213] Fish make a slightly different form called 11-ketotestosterone.[214] Its counterpart in insects is ecdysone.[215] The presence of these ubiquitous steroids in a wide range of animals suggest that sex hormones have an ancient evolutionary history.[216]

See also[edit]

  • List of androgens/anabolic steroids
  • List of human hormones

References[edit]

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  216. ^ Mechoulam R, Brueggemeier RW, Denlinger DL (September 1984). «Estrogens in insects». Cellular and Molecular Life Sciences. 40 (9): 942–44. doi:10.1007/BF01946450. S2CID 31950471.

Further reading[edit]

  • Fargo KN, Pak TR, Foecking EM, Jones KJ (2010). «Molecular Biology of Androgen Action: Perspectives on Neuroprotective and Neurotherapeutic Effects.». In Pfaff DW, Etgen AM (eds.). Molecular Mechanisms of Hormone Actions on Behavior. Elsevier Inc. pp. 1219–1246. doi:10.1016/B978-008088783-8.00036-X. ISBN 978-0-12-374939-0.
  • Dowd NE (2013). «Sperm, testosterone, masculinities and fatherhood». Nevada Law Journal. 13 (2): 8.
  • Celec P, Ostatníková D, Hodosy J (February 2015). «On the effects of testosterone on brain behavioral functions». Frontiers in Neuroscience. 9: 12. doi:10.3389/fnins.2015.00012. PMC 4330791. PMID 25741229.
Источник

Содержание

  • Структурная формула
  • Русское название
  • Английское название
  • Латинское название вещества Тестостерон
  • Химическое название
  • Брутто формула
  • Фармакологическая группа вещества Тестостерон
  • Нозологическая классификация
  • Код CAS
  • Фармакологическое действие
  • Характеристика
  • Фармакология
  • Применение вещества Тестостерон
  • Противопоказания
  • Ограничения к применению
  • Применение при беременности и кормлении грудью
  • Побочные действия вещества Тестостерон
  • Взаимодействие
  • Передозировка
  • Способ применения и дозы
  • Меры предосторожности
  • Источники информации
  • Торговые названия с действующим веществом Тестостерон

Структурная формула

Структурная формула Тестостерон

Русское название

Тестостерон

Английское название

Testosterone

Латинское название вещества Тестостерон

Testosteronum (род. Testosteroni)

Химическое название

(17бета)-17-Гидроксиандрост-4-ен-3-он

Фармакологическая группа вещества Тестостерон

Фармакологическое действие

Фармакологическое действие

—

андрогенное, анаболическое, противоопухолевое.

Характеристика

Мужской половой гормон, андроген. Синтезируется клетками Лейдига семенников у мужчин, а также в небольших количествах яичниками у женщин и корой надрочечников и у мужчин, и у женщин.

В медицинской практике применяется в виде собственно тестостерона и его эфиров — пропионата, ундеканоата, ципионата и энантата.

Фармакология

Фармакодинамика

Основной эндогенный андроген, ответственный за рост и развитие мужских половых органов и поддержание вторичных половых признаков. Эти эффекты включают рост и созревание простаты, семенных пузырьков, полового члена и мошонки; развитие мужского типа распределения волос, например на лице, лобке, груди и подмышечных впадинах; увеличение гортани, утолщение голосовых связок и изменение мускулатуры тела и распределение жира.

Андрогены также вызывают задержку азота, натрия, калия и фосфора и снижение экскреции кальция с мочой. Андрогены увеличивают анаболизм белков и снижают катаболизм белков. Баланс азота улучшается только при достаточном потреблении калорий и белка.

Во многих тканях активность тестостерона зависит от восстановления до дигидротестостерона, который связывается с белками рецептора в цитозоле. Комплекс стероид–рецептор транспортируется в ядро, где он инициирует события транскрипции и клеточные изменения, связанные с действием андрогенов.

Андрогены ответственны за всплеск роста в подростковом возрасте и за возможное прекращение линейного роста, вызванное слиянием эпифизарных центров роста. У детей экзогенные андрогены ускоряют линейную скорость роста, но могут вызывать непропорциональное ускорение созревания костей. Использование в течение длительного времени может привести к слиянию эпифизарных центров роста и прекращению процесса роста. Андрогены стимулируют выработку красных кровяных телец за счет увеличения выработки фактора эритропоэтической стимуляции.

Во время экзогенного введения андрогенов высвобождение эндогенного тестостерона подавляется за счет ингибирования ЛГ по принципу обратной связи. При больших дозах экзогенных андрогенов может также подавляться сперматогенез за счет ингибирования ФСГ по принципу обратной связи. Отсутствуют убедительные доказательства эффективности андрогенов при переломах, хирургических вмешательствах и функциональном маточном кровотечении.

В результате недостаточной секреции тестостерона возникает клинический синдром — мужской гипогонадизм, который имеет две основные этиологии. Первичный гипогонадизм вызывается дефектами гонад, такими как синдром Клайнфельтера или аплазия клеток Лейдига, вторичный гипогонадизм — это неспособность гипоталамуса (или гипофиза) вырабатывать достаточное количество ЛГРГ (или гоандотропинов — ФСГ или ЛГ).

Фармакокинетика

Абсорбция и распределение

Эфиры тестостерона менее полярны, чем свободный тестостерон. При в/м введении масляных растворов эфиры тестостерона абсорбируются из липидной фазы и в результате расщепления боковой цепи тканевыми эстеразами высвобождается тестостерон.

Тестостерон в плазме крови связывается со специфическим ГСПГ (до 98%), оставшаяся часть — с альбумином или находится в свободном состоянии.

При трансдермальном применении системная абсорбция составляет 10% от примененной дозы.

Время достижения пикового уровня при в/м введении составляет для тестостерона ундеканоата 7 дней (медиана; диапазон от 4 до 42 дней), тестостерона при интраназальном введении — 40 мин, при трансдермальном применении — 8 ч (диапазон от 4 до 12 ч), при пероральном приеме — от 2 до 5 ч и при применении в виде п/к импланта (тестостерона энантат) — 11 ч (медиана; диапазон от 5,8 до 166,7 ч).

Продолжительность действия зависит от пути введения и вида эфира и составляет для в/м тестостерона ципионата и энантата от 2 до 4 нед и тестостерона ундеканоата 18 нед. Продолжительность действия для наружного применения — 24 ч.

Метаболизм

Тестостерон метаболизируется в печени до различных 17-кетостероидов двумя разными путями. Основными активными метаболитами тестостерона являются эстрадиол и дигидротестостерон.

Выведение

T1/2 тестостерона значительно варьирует от 10 до 100 мин. T1/2 тестостерона ципионата при в/м введении составляет примерно 8 дней.

Около 90% дозы тестостерона, введенной в/м, выводится с мочой в виде конъюгатов с глюкуроновой, серной кислотами и других метаболитов. Около 6% дозы выводится с калом, преимущественно в неконъюгированной форме.

Применение вещества Тестостерон

Задержка полового созревания у лиц мужского пола (в/м, п/к).

Гипогонадизм гипогонадотропный (врожденный или приобретенный) — дефицит гонадотропина или ЛГРГ или гипофизарно-гипоталамическое повреждение опухолями, травмами или радиацией (все пути введения).

Гипогонадизм первичный (врожденный или приобретенный) — лечение недостаточности семенников, вызванной крипторхизмом, двусторонним перекрутом, орхитом, синдромом исчезновения яичка, орхиэктомией, синдромом Клайнфельтера, химиотерапией или токсическим повреждением от алкоголя или тяжелых металлов (все пути введения).

Прогрессирующий неоперабельный метастатический рак молочной железы у женщин в периоде постменопаузы от 1 до 5 лет (в/м, вспомогательное лечение). Использование может быть рассмотрено у женщин в пременопаузе с гормонозависимым раком молочной железы, которым выполнена овариэктомия.

Противопоказания

Повышенная чувствительность к тестостерону и его эфирам, рак молочной железы (у мужчин), рак простаты (известный или подозреваемый), беременность, лактация, применение у женщин, которые в состоянии забеременеть.

Дополнительно:

— для депо-тестостерона (тестостерона ципионат) — серьезные заболевания сердца, печени или почек;

— для тестостерона энантата (п/к) и ундеканоата (внутрь) — применение у мужчин с гипогонадическими состояниями, не связанными со структурной или генетической этиологией (например, возрастной гипогонадизм).

Ограничения к применению

Безопасность и эффективность применения тестостерона у мужчин с возрастным гипогонадизмом (гипогонадизм с поздним началом) не установлены. Тем не менее рекомендуется предлагать терапию тестостероном пациентам с симптомами дефицита тестостерона, имеющим постоянно и однозначно низкие концентрации тестостерона в крови по утрам. У мужчин старше 65 лет лечение следует начинать только в индивидуальном порядке и после консультации с пациентом относительно рисков и преимуществ такого лечения.

Применение при беременности и кормлении грудью

Противопоказано применение при беременности и кормлении грудью, а также у женщин, которые в состоянии забеременеть.

Тестостерон может причинить вред плоду при введении беременной женщине и вызвать серьезные побочные реакции у грудных детей. Воздействие андрогенов на плод или грудного ребенка может привести к различной степени вирилизации.

Побочные действия вещества Тестостерон

Ниже перечислены нежелательные реакции, отмечавшиеся при применении всех лекарственных форм тестостерона и его эфиров с указанием общей частоты их развития и/или в зависимости от пути введения.

Очень часто (>10%)

Со стороны ССС: гипертония (≤13%; интраназально — >6%).

Со стороны кожи: волдыри и зуд в месте трансдермального нанесения (12%).

Со стороны мочеполовой системы: повышение уровня специфического антигена простаты (≤18%; внутрь — 2%), ДГПЖ (12%).

Гематологические и онкологические нарушения: повышенный гематокрит (п/к — от 8 до 14%; наружно, внутрь — ≤6%; в/м — 1%).

Часто (от 1 до 10%)

Со стороны ССС: периферические отеки (<1%; п/к — 3%), заболевания периферических сосудов (трансдермально — <3%).

Со стороны ЦНС: эмоциональная лабильность (в/м, наружно — ≤3%), изменение обоняния (интраназально — от 5 до >6%; местно — 1%), аносмия (интраназально — 6%), головная боль (≤5%), процедурная боль (в/м, интраназально — 4%), депрессия (≤3%), нервозность (≤3%), нарушение мышления (трансдермально — <3%), беспокойство (<3%), боль в теле (трансдермально — <3%), озноб (трансдермально — <3%), спутанность сознания (трансдермально — <3%), усталость (<3%), парестезия (<3%), головокружение (трансдермально — <3%), раздражительность (в/м — 2%), апноэ во сне (2%), бессонница (в/м, п/к, наружно — от 1 до 2%), агрессивное поведение (в/м — 1%).

Со стороны кожи: акне (≤8%), корка на коже носа (интраназально — от 4 до 6%), раздражение кожи (интраназально — ≤6%), контактный дерматит (трансдермально — от 2 до 4%) ), булла (трансдермально — <3%), кожная сыпь (<3%), зуд (≤2%), ксеродермия (наружно — ≤2%), эритема (наружно — ≥1%), гипергидроз (в/м — 1%), алопеция (наружно — ≤1%).

Эндокринные и метаболические нарушения: снижение уровня Хс-ЛПВП (наружно, перорально — ≤6%), гиперлипидемия (≤6%), гипокалиемия (наружно — ≤6%), повышение уровня триглицеридов в сыворотке крови (≤6%), повышение уровня ТТГ (интраназально — ≤6%), повышение концентрации эстрадиола в плазме (в/м — 3%), снижение либидо (≤3%), гинекомастия (≤3%), приливы (в/м, наружно — 1%), увеличение массы тела (в/м — 1%).

Со стороны ЖКТ: снижение аппетита (интраназально — ≤6%), тошнота (≤6%; перорально, п/к — 2%), диарея (≤4%), дисгевзия (<3%), ГЭРБ (трансдермально — <3%), желудочно-кишечное кровотечение (трансдермально — <3%), повышение аппетита (наружно, трансдермально — <3%), боль в животе (п/к — 2%). 

Со стороны мочеполовой системы: атрофия яичек (интраназально, наружно — ≤6%), заболевание предстательной железы (наружно, трансдермально — от 3 до 5%), гипогонадизм (в/м — 3%), масталгия (наружно — ≤3%), простатит (в/м, п/к, трансдермально — ≤3%), инфекция мочевыводящих путей (п/к, трансдермально — ≤3%), дизурия (в/м, трансдермально — <3%), гематурия (п/к, трансдермально — <3%), импотенция (трансдермально — <3%), тазовая боль (трансдермально — <3%), недержание мочи (трансдермально — <3%), заболевание яичек (включая болезненность и непальпируемые яички, наружно — 2%), частое мочеиспускание (наружно — ≤2%), затрудненное мочеиспускание (наружно — 1%), нарушение эякуляции (в/м — 1%), уплотнение простаты (в/м — 1%), спонтанная эрекция (наружно — 1%).

Гематологические и онкологические нарушения: анемия (наружно — 3%), полицитемия (≤3%), карцинома простаты (наружно, трансдермально — <3%), повышение уровня Hb (в/м, наружно — ≤2%).

Со стороны печени: повышение уровня билирубина в сыворотке (наружно — ≤6%), аномальные функциональные пробы печени (1%).

Со стороны почек: повышение креатинина сыворотки (наружно — ≤6%), полиурия (трансдермально — <3%).

Со стороны органов дыхания: ринофарингит (интраназально — от 4 до 9%; наружно — ≤1%), ринорея (интраназально — от 4 до 8%), носовое кровотечение (интраназально — от 4 до 7%), дискомфорт в носу (интраназально — от 4 до 6%), бронхит (интраназально — 4%), инфекции верхних дыхательных путей (интраназально — 4%), сухость в носу (интраназально — ≤4%), заложенность носа (интраназально — ≤4%), синусит (в/м, интраназально — ≤4 %), кашель (в/м, интраназально, п/к — ≤3%).

Со стороны нервно-мышечной и скелетной системы: боль в спине (п/к, трансдермально — от 3 до 6%), миалгия (в/м, интраназально — ≤6%), боль в конечностях (интраназально, наружно — ≤4%), повышение уровня КФК в образце крови (п/к — от 3 до 4%), астения (наружно — ≤3%), аномальный рост костей (ускоренный; трансдермально — <3%), гемартроз (трансдермально — <3%), артралгия (п/к — 2%).

Местные реакции: синяки в месте инъекции (п/к — от 4 до 7%), эритема в месте нанесения (наружно, трансдермально — ≤7%), пузырьки в месте аппликации (трансдермально — 6%), кровотечение в месте инъекции (п/к — от 3 до 6%), реакция в месте нанесения (наружно — ≤6%), боль в месте инъекции (в/м — 5%), уплотнение в месте нанесения (трансдермально — 3%), эритема в месте инъекции (п/к — 3%; в/м — 1%), раздражение в месте нанесения (трансдермально — <3%), сыпь в месте нанесения (трансдермально — <3%), местное отшелушивание кожи (трансдермально, наружно — <3%), жжение в месте нанесения (наружно, трансдермально — от 1 до 3%), отек в месте нанесения (наружно — ≥1%).

Частота не определена

Со стороны ЦНС: агрессивность (наружно).

Со стороны печени: аденома печени (в/м; длительная терапия тестостерона энантатом).

Местные реакции: уплотнение в месте инъекции (п/к).

Менее 1%, постмаркетинговые и/или клинические случаи

Абсцесс в месте инъекции, острый инфаркт миокарда, аллергический дерматит, измененный уровень гормонов (колебания уровня тестостерона), амнезия, анафилактический шок, анафилаксия, андрогенная алопеция, стенокардия, ангионевротический отек, астма, азооспермия, горький вкус, уплотнение молочной железы, задержка кальция, сердечная недостаточность, инфаркт головного мозга, нарушение мозгового кровообращения, цереброваскулярная недостаточность, изменение уровня ЛПВП, боль в молочной железе, холестатическая желтуха, ХОБЛ, циркуляторный шок, подавление факторов свертывания (факторы II, V, VII, X), ИБС, окклюзия коронарных артерий, снижение уровня тестостерона в плазме, снижение уровня тироксинсвязывающего глобулина, тромбоз глубоких вен, сахарный диабет, потоотделение, дискомфорт в месте инъекции, головокружение, злоупотребление наркотиками, одышка, отек, нарушение уровня электролитов (кальций, азот, фосфор, калий, натрий), эректильная дисфункция, задержка жидкости, симптомы гриппа, частые эрекции, мочеполовая инфекция (простата), эритема десен, изменение цвета волос, потеря слуха (внезапная), гематома в месте инъекции, новообразование печени, гепатоцеллюлярное новообразование, гепатотоксичность, гирсутизм, гиперхлоремия, гипернатриемия, гиперпаратиреоз, гиперчувствительный ангиит, реакция гиперчувствительности, гипервентиляция, повышение уровня ГГТ, повышение серотоксин-глутамилтрансферазы, аспартатаминотрансфераза в сыворотке крови, повышение уровня пролактина в сыворотке крови, повышение уровня трансаминаз в сыворотке крови, повышение уровня тестостерона, инфекция, реакция в месте инъекции, задержка неорганического фосфата, раздражение в месте инъекции, синдром Корсакова (безалкогольный), отек губ, очаговая инфекция (абсцесс), целлюлит, недомогание, злокачественное новообразование простаты, мигрень, скелетно-мышечная боль в груди, скелетно-мышечная боль, нефролитиаз, болезненность сосков (чувствительность), неиммунная анафосилаксия (может возникнуть при высоких дозах), воспаление полости рта, язва слизистой оболочки полости рта, нарушение оргазма (у мужчин), остеопороз, папулезная сыпь, пелиозный гепатит, периферическая венозная недостаточность, отек глотки, боль в глотке, поллакиурия, задержка калия, приапизм, длительное АЧТВ, пролонгированное ПВ, интраэпителиальная неоплазия предстательной железы, легочная эмболия (включая легочную масляную микроэмболию), почечная колика, нарушение функции почек, почечная боль, респираторный дистресс, беспокойство,обратимый ишемический неврологический дефицит, ринит, нарушение сна, храп, задержка натрия, сперматоцеле, стоматит, суицидальные мысли, обморок, СКВ, тахикардия, боль в яичках, тромбоцитопения, тромбоэмболия, тромбоз артерий верхних отделов брюшной полости, боль в ушах, преходящая боль при мочеиспускании, вазодилатация, венозная тромбоэмболия, отслойка стекловидного тела, нарушение голоса, ксеростомия.

Взаимодействие

Инсулин. У пациентов, принимающих андрогены, могут наблюдаться изменения чувствительности к инсулину или гликемического контроля. У пациентов с сахарным диабетом метаболические эффекты андрогенов могут выражаться в снижении уровня глюкозы в крови и, следовательно, могут потребовать снижения дозы антидиабетических ЛС.

Пероральные антикоагулянты. Изменения антикоагулянтной активности могут наблюдаться при применении андрогенов, поэтому у пациентов, принимающих варфарин, рекомендуется более частый мониторинг МНО и ПВ, особенно в начале и при прекращении терапии андрогенами. Может потребоваться снижение дозы антагониста витамина К.

Кортикостероиды. Одновременное применение тестостерона с кортикостероидами может привести к увеличению задержки жидкости и требует тщательного наблюдения, особенно у пациентов с заболеваниями сердца, почек или печени.

Оксифенбутазон. Одновременное применение оксифенбутазона и андрогенов может привести к повышению уровня оксифенбутазона в сыворотке крови.

Аймалин. Андрогены могут усиливать неблагоприятное/токсическое действие аймалина. В частности, может увеличиваться риск развития холестаза.

Ингибиторы С1 фактора комполемента. Андрогены могут усиливать тромбогенный эффект ингибиторов C1.

Циклоспорин (системный). Андрогены могут повышать концентрацию циклоспорина в сыворотке крови и усиливать его гепатотоксический эффект. Рекомендуется избегать одновременного приема андрогенов и циклоспорина. Если одновременное применение неизбежно, необходимо контролировать концентрацию циклоспорина в сыворотке крови, а также признаки и симптомы гепатотоксичности. Может потребоваться снижение дозы циклоспорина.

Дегидроэпиандростерон может усиливать неблагоприятное/токсическое действие тестостерона. Следует избегать совместного применения.

Передозировка

Симптомы: имеется одно сообщение об острой передозировке с использованием одобренного инъекционного тестостерона; пациент имел уровень тестостерона в сыворотке крови до 11400 нг/дл с нарушением мозгового кровообращения.

Лечение: прекращение применения тестостерона и проведение соответствующей симптоматической и поддерживающей терапии.

Способ применения и дозы

В/м, внутрь, п/к, интраназально, наружно. Режим дозирования и схемы применения зависят от заболевания, возраста и пола пациента, а также применяемой лекарственной формы.

Меры предосторожности

Злоупотребление и зависимость. Злоупотреблением является преднамеренное, даже однократное, нетерапевтическое применение ЛС благодаря его психологическим и физиологическим эффектам. Злоупотребление и неправильное использование тестостерона наблюдается у взрослых мужчин и женщин, а также у подростков. Имеются сообщения о злоупотреблении мужчинами, принимающими более высокие дозы легально полученного тестостерона, чем предписанные, и продолжающих прием тестостерона, несмотря на побочные эффекты или вопреки рекомендациям врача.

Сообщалось о серьезных побочных реакциях у лиц, злоупотребляющих анаболическими андрогенными стероидами, включая остановку сердца, инфаркт миокарда, гипертрофическую кардиомиопатию, застойную сердечную недостаточность, нарушение мозгового кровообращения, гепатотоксичность и серьезные психиатрические проявления, в т.ч. большую депрессию, манию, паранойю, психоз, бред, галлюцинации, неприязнь и агрессия.

Сообщалось также о следующих побочных реакциях у мужчин: транзиторные ишемические атаки, судороги, гипомания, раздражительность, дислипидемии, атрофия яичек, недостаточная фертильность и бесплодие. Сообщалось о следующих дополнительных побочных реакциях у женщин: гирсутизм, вирилизация, огрубление голоса, увеличение клитора, атрофия молочных желез, облысение по мужскому типу и нарушения менструального цикла.

Сообщалось о следующих побочных реакциях у подростков мужского и женского пола: преждевременное закрытие костных эпифизов с прекращением роста и преждевременное половое созревание.

Ввиду того что такие сообщения поступают в добровольном порядке от неопределенного круга лиц и могут включать злоупотребление другими веществами, не всегда возможно надежно оценить их частоту или установить причинную связь с воздействием тестостерона.

Продолжительное злоупотребление тестостероном и другими анаболическими стероидами может приводить к зависимости. Физическая зависимость характеризуется симптомами отмены после резкого прекращения приема или значительного снижения дозы ЛС. У людей, принимающих сверхтерапевтические дозы тестостерона, могут наблюдаться симптомы отмены, продолжающиеся в течение недель или месяцев, которые включают подавленное настроение, большую депрессию, усталость, тягу, беспокойство, раздражительность, анорексию, бессонницу, снижение либидо и гипогонадотропный гипогонадизм. Лекарственная зависимость у лиц, использующих утвержденные дозы тестостерона по утвержденным показаниям, не документирована.

Повышение АД. Повышение АД наблюдалось при пероральном приеме тестостерона ундеканоата и п/к введении тестостерона энантата. Об этом эффекте сообщалось и при применении других препаратов тестостерона. Следует проверять АД до начала терапии, примерно через 3–6 нед после ее начала, а затем периодически. Некоторым пациентам может потребоваться начало или корректировка антигипертензивной терапии.

Рак молочной железы. Длительное (>10 лет) парентеральное применение тестостерона при мужском гипогонадизме может повысить риск развития рака молочной железы.

Сердечно-сосудистые события. Имеющиеся исследования не позволяют сделать окончательных выводов в отношении риска развития серьезных неблагоприятных сердечно-сосудистых событий, таких как нефатальный инфаркт миокарда, инсульт или смерть от сердечно-сосудистых заболеваний после применения тестостерона. Некоторые исследования предполагают повышенный риск развития сердечно-сосудистых событий среди групп мужчин, которым назначена терапия тестостероном, хотя общие данные не демонстрируют повышенного или пониженного риска сердечно-сосудистых заболеваний. Согласно FDA, терапию тестостероном следует назначать только мужчинам с низким уровнем тестостерона, вызванным определенными заболеваниями (например, заболеваниями семенников, гипофиза, головного мозга) и подтвержденным лабораторными тестами. В заявлении, опубликованном Американской ассоциацией клинических эндокринологов (AACE) и Американским колледжем эндокринологии (ACE), рекомендуется, чтобы после тщательного диагностического обследования при заместительной терапии тестостероном руководствовались признаками и симптомами и концентрацией тестостерона в крови, а не первопричиной. Рекомендуется избегать терапии тестостероном у мужчин, перенесших инфаркт миокарда или инсульт в течение последних 6 мес. Перед началом терапии следует оценивать факторы риска развития сердечно-сосудистых заболеваний и внимательно следить за сердечно-сосудистыми событиями во время терапии.

Дислипидемия. Применение тестостерона может изменять липидный профиль сыворотки крови. Следует соблюдать осторожность при наличии инфаркта миокарда или ИБС в анамнезе.

Гинекомастия. Применение тестостерона может вызывать гинекомастию, которая может сохраняться у пациентов, леченных от гипогонадизма.

Воздействие на печень. Длительное применение высоких доз андрогенов может приводить к серьезным поражениям печени (пелиоз печени, новообразования печени, холестатический гепатит, желтуха). Длительное в/м введение тестостерона энантата было связано с множественными аденомами печени. Если развиваются признаки или симптомы нарушения функции печени (например, желтуха), терапию следует прекратить.

Гиперкальциемия. Андрогены могут вызывать гиперкальциемию у пациентов с длительной иммобилизацией или раком.

Полицитемия. Возможно повышение гематокрита, что потребует корректировки дозы или отмены. Необходимо прекратить лечение у пациентов с гематокритом >48 или >50%, если они живут на больших высотах. Терапию следует прекратить, если гематокрит превышает 54%; возможно возобновление терапии с применением более низкой дозы.

Приапизм. Возможно развитие приапизма или чрезмерной сексуальной стимуляци. В этих случаях терапию необходимо приостановить, при возобновлении лечения следует использовать более низкую дозу.

Рак простаты. Может увеличиться риск развития рака простаты. Следует отказаться от терапии до проведения урологического обследования у пациентов с пальпируемым узлом простаты или уплотнениями, ПСА >4 или ПСА >3 нг/мл у мужчин с высоким риском развития рака простаты.

Венозная тромбоэмболия. При приеме препаратов тестостерона сообщалось о случаях развития венозной тромбоэмболии, включая ТГВ и ТЭЛА. Необходимо обследовать пациентов с симптомами боли, отека, тепла и эритемы в нижних конечностях на предмет ТГВ и пациентов с острой одышкой на предмет ТЭЛА. При подозрении на венозную тромбоэмболию терапию следует прекратить. Не рекомендуется использование тестостерона у мужчин с гипогонадизмом и тромбофилией.

Легочная масляная микроэмболия. При инъекции масляных растворов тестостерона ундеканоата были зарегистрированы серьезные, в т.ч. опасные для жизни, случаи развития легочной масляной микроэмболии и анафилаксии. Реакции включали анафилаксию, боль в груди, позыв к кашлю, головокружение, одышку, сжатие в горле и обморок. Эти реакции могут возникнуть после любой инъекции во время курса терапии, включая первую дозу. Пациенты должны находиться под наблюдением в течение 30 мин после инъекции. Чтобы свести к минимуму риск развития побочных реакций, препарат следует вводить глубоко в ягодичную мышцу. Также поступали редкие сообщения о реакциях, включающих позывы к кашлю, приступы кашля и респираторный дистресс сразу после в/м инъекции тестостерона энантата (препарат депо на масляной основе).

ДГПЖ. Андрогены могут ухудшить течение ДГПЖ, их использование у пациентов с тяжелыми симптомами со стороны нижних мочевыводящих путей не рекомендуется. Терапию следует прекратить, если у пациентов с ДГПЖ развивается обструкция уретры (при возобновлении лечения используется меньшая доза).

Депрессия. Следует соблюдать осторожность при применении тестостерона у пациентов с депрессией, тестостерон может повысить риск развития депрессии и суицидальных мыслей. Необходимо производить оценку состояния пациентов с впервые возникшей или усиливающейся депрессией, тревогой, изменениями настроения или суицидальными идеями или поведением.

Заболевания, усугубляемые задержкой жидкости. Следует соблюдать осторожность у пациентов с заболеваниями, которые могут усугубляться задержкой жидкости, включая сердечную недостаточность; тестостерон может вызвать задержку жидкости. Лечение синдромов андрогенной недостаточности не рекомендуется мужчинам с неконтролируемой или плохо контролируемой сердечной недостаточностью.

Печеночная и почечная недостаточность. Тестостерон может вызвать задержку жидкости. Следует соблюдать осторожность при применении тестостерона у пациентов с печеночной и почечной недостаточностью; тестостерона ципионат противопоказан при серьезном нарушении функции печени или почек.

Апноэ во сне. Тестостерон может усилить апноэ во сне у некоторых пациентов мужского пола, особенно у пациентов с факторами риска (например, ожирение или хроническое заболевание легких). Необходимо отказаться от начала лечения пациентов с нелеченым синдромом обструктивного апноэ во сне.

Фертильность. Большие дозы тестостерона могут подавлять сперматогенез, влияние на фертильность может быть необратимым. Лечение гипогонадотропного гипогонадизма тестостероном не рекомендуется мужчинам, желающим зачать ребенка, в течение 6–12 мес.

Особые группы пациентов

Пожилой возраст. Гериатрические пациенты могут подвергаться большему риску развития ДГПЖ, рака простаты, задержки жидкости и повышения уровня трансаминаз. Заместительная терапия тестостероном у пациентов старше 65 лет обычно не рекомендуется и должна рассматриваться только в каждом конкретном случае, если присутствуют состояния или симптомы, указывающие на низкий уровень тестостерона, наряду с постоянно и однозначно низкими концентрациями тестостерона в крови по утрам.

Дети. Тестостерон может ускорить созревание костей (без компенсации линейного роста) и преждевременное закрытие эпифиза у детей. У детей препубертатного возраста необходимо каждые 6 мес проводить рентгенологическое исследование кисти и запястья для определения скорости созревания костей и оценки воздействия лечения на эпифизарные области. Следует соблюдать осторожность при применении тестостерона у пациентов с задержкой полового созревания. Некоторые тестостеронсодержащие ЛС не одобрены для использования у пациентов младше 18 лет.

Женщины. Во время лечения метастатического рака молочной железы женщины должны находиться под наблюдением на предмет признаков вирилизации. Следует прекратить лечение, если присутствует легкая вирилизация, чтобы предотвратить необратимые симптомы.

Опосредованное воздействие

Тестостерон может передаваться другому человеку при контакте кожа к коже с местом нанесения. Сообщалось о вирилизации у детей в результате таких контактов. Детям и женщинам следует избегать контакта с местами нанесения у мужчин, использующих препараты тестостерона для наружного применения.

Особенности, связанные с отдельными лекарственными формами тестостерона

Инъекции тестостерона ципионата не следует использовать взаимозаменяемо с тестостерона пропионатом из-за различий в продолжительности действия.

Трансдермальный пластырь может содержать металл (например, алюминий), который может нагреваться и повреждать кожу при проведении МРТ, перед МРТ пластырь необходимо удалить.

Раствор для наружного применения не взаимозаменяем с другими лекарственными формами тестостерона для наружного применения. Применение у мужчин с ИМТ >35 кг/м2 не изучалось.

Параметры мониторинга

До начала лечения. Подтверждение гипогонадизма измерением общего уровня тестостерона в сыворотке по крайней мере 2 раза утром после ночного голодания. Функциональные пробы печени, липидный профиль, Hb и гематокрит (воздержаться от начала лечения у пациентов с гематокритом >48% или >50% у мужчин, живущих на больших высотах). Исследование ПСА и простаты у мужчин от 55 до 69 лет или ≥40 лет и с повышенным риском развития рака простаты (воздержаться от лечения до урологического обследования у пациентов с пальпируемым узлом простаты или уплотнением простаты, или, если уровень ПСА >4 нг/мл или ПСА >3 нг/мл у мужчин с высоким риском развития рака простаты); контроль АД.

Во время лечения. Контроль АД (от 3 до 6 нед после начала приема или корректировки дозировки и периодически после этого); функциональные тесты печени; липидный профиль, Hb и гематокрит (через 3–6 мес, через 12 мес, затем ежегодно, прекратить терапию, если гематокрит превышает 54%). Контроль содержания кальция в моче и сыворотке и признаков вирилизации у женщин с раком молочной железы. Уровень глюкозы в сыворотке (может снижаться под действием тестостерона, контроль состояния пациентов с диабетом). Оценивать реакцию мужчин на лечение и побочные эффекты через 3–12 мес после начала лечения, а затем ежегодно; внимательное наблюдение за сердечно-сосудистыми событиями во время терапии.

Рентгенологический контроль МПКТ запястья и кисти у детей препубертатного возраста каждые 6 мес.

Мужчины с гипогонадизмом, остеопорозом или переломом с малой травмой — наблюдение через 1–2 года лечения. Контроль ПСА и простаты в период от 3 до 12 мес, затем в соответствии с текущими рекомендациях по скринингу рака простаты.

Свободный тестостерон следует измерять у пациентов с состояниями, связанными с повышенным или пониженным уровнем ГСПГ, или у пациентов с концентрацией общего тестостерона в пограничной зоне около нижнего предела нормального диапазона (например, от 200 до 400 нг/дл).

Определение общего уровня тестостерона в крови в период от 3 до 6 мес после начала лечения (в зависимости от лекарственной формы), через 12 мес, затем каждые 6–12 мес.

Источники информации

Обобщенные материалы www.drugs.com и www.rxlist.com, 2020 г.

Торговые названия с действующим веществом Тестостерон

Торговое название Цена за упаковку, руб.
Андрогель®

от 2695.00 до 2975.00
Небидо®

от 5759.00 до 5759.00
Источник

Тестостерон

Поиск химических веществ по названиям или формулам.

Справочник содержит названия веществ и описания химических формул (в т.ч. структурные формулы и скелетные формулы).

Введите часть названия или формулу для поиска:

Тестостерон

Брутто-формула:
C19H28O2

CAS# 58-22-0

Названия

Русский:

English:

(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one(IUPAC)
Androderm
Androlin
Andropatch
Delatestryl
Mertestate
Oreton
Sustanon
Testim
Testoderm
Testosteron
Testosterone

German:

17β-Hydroxyandrost-4-en-3-on
4-Androsten-17β-ol-3-on
Testosteron

العربية:

Ελληνικά:

Español:

(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one(IUPAC)
Testosterona

French:

17β-hydroxyandrost-4-èn-3-one(IUPAC)
Testostérone

हिन्दी:

Italiano:

(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Testosterone

日本語:

中文:

Latina:

Варианты формулы:

|`/«|<`|w>«/|`/O///`|0/<`|wH>/<|dH>`|_p<_(A-72,w+)OH>_p_p_p`|0<`|w>«/|c|dH

H|/<_(y1,S:)H>`|/<`|OH><_(A-15,S:)H>|_#3`|0<`|H3C>«/||`/«|<`|H3C>«/|`/O///`|0/_(y1,S:)H
Источник

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